{"id":"W2019922908","doi":"10.1073/pnas.1402134111","title":"Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Emory University; National Institute on Aging; National Institutes of Health","keywords":"Vesicular monoamine transporter 2; Vesicular monoamine transporter; Dopamine; Substantia nigra; Monoamine neurotransmitter; Vesicular transport protein; Pars compacta; Dopaminergic; MPTP; Dopamine transporter; Neurodegeneration; Biology; Neuroprotection; Striatum; Parkinson's disease; Pharmacology; Internal medicine; Endocrinology; Serotonin; Biochemistry; Medicine; Vesicle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422832,0.0004744586,0.0004578588,0.0003566701,0.000130562,0.0004073756,0.0002497435,0.0004675559,0.001028455],"category_scores_gemma":[0.0001369008,0.0002151397,0.0002047998,0.0001284634,0.0003716615,0.0003719942,0.0002773638,0.0005993202,0.0002554715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002797204,"about_ca_system_score_gemma":0.0001876482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003851707,"about_ca_topic_score_gemma":0.0008107898,"domain_scores_codex":[0.9998237,0.00003364653,0.00002161091,0.00004405115,0.00004318015,0.00003384991],"domain_scores_gemma":[0.9998268,0.00001941114,0.00006016179,0.00001981792,0.0000162827,0.00005740941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651321,0.00005706367,0.0001329434,0.00001874456,0.000007439847,0.00002544029,0.000007245013,0.00002424389,0.9988719,0.00007232984,0.00002240266,0.000595254],"study_design_scores_gemma":[0.0001002521,0.00218522,0.004203408,0.00000906294,0.00004169127,0.0003293907,0.00002205543,0.0008395531,0.9905122,0.00008869041,0.001660719,0.000007746068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959589,0.0008515081,0.001885818,0.0001423876,0.00004549042,0.00002852697,0.0001667526,0.0001330507,0.0007875861],"genre_scores_gemma":[0.9936509,0.000881744,0.002849312,0.00005979416,0.000020262,0.00004297187,0.0003798668,0.00004188741,0.002073383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028455,"threshold_uncertainty_score":0.003440499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919692233862056,"score_gpt":0.2623319329210307,"score_spread":0.2431350105824101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}