{"id":"W2019929978","doi":"10.1016/j.ijpharm.2015.03.028","title":"Design and preclinical characterization of a novel vaccine adjuvant formulation consisting of a synthetic TLR4 agonist in a thermoreversible squalene emulsion","year":2015,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Adjuvant; Squalene; Agonist; Chemistry; Pharmacology; Receptor; Medicine; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003637208,0.0003587404,0.0001925946,0.0002054687,0.0001078007,0.0002010366,0.0002291634,0.0002814372,0.001160992],"category_scores_gemma":[0.0002104588,0.0001774258,0.0002754821,0.00007809568,0.0001582872,0.0002811328,0.0001653361,0.0005283751,0.000348432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130301,"about_ca_system_score_gemma":0.0003847817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002654916,"about_ca_topic_score_gemma":0.0003798626,"domain_scores_codex":[0.9999105,0.00001169798,0.00000811686,0.00001738298,0.00002680229,0.00002555303],"domain_scores_gemma":[0.9999125,0.00001357689,0.00002904321,0.000006795733,0.00002138771,0.00001667115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002264277,0.000188194,0.00007421331,0.00004783034,0.00000575907,0.00001998617,0.000007508349,0.0003686921,0.9962714,0.0001075156,0.00003926208,0.002643158],"study_design_scores_gemma":[0.00008977397,0.003601486,0.0003266891,0.000005672824,0.00003434406,0.00006966013,0.000007969488,0.001304446,0.9918689,0.00004045674,0.002646092,0.000004601934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794375,0.001399873,0.01695331,0.0001813541,0.00009468078,0.0004047125,0.0003039613,0.00008344799,0.001141073],"genre_scores_gemma":[0.9816679,0.001189909,0.0129161,0.0001025979,0.00002898546,0.000214961,0.0004191216,0.00002376579,0.003436518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160992,"threshold_uncertainty_score":0.003883839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09099088089401106,"score_gpt":0.3657740313526456,"score_spread":0.2747831504586346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}