{"id":"W2019931617","doi":"10.1016/j.bone.2012.11.007","title":"Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions","year":2012,"lang":"en","type":"article","venue":"Bone","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Ministerio de Economía y Competitividad; Universitat de Barcelona; Mountain Equipment Co-operative","keywords":"RUNX2; Transactivation; Promoter; Enhancer; Gene isoform; Transcription factor; Gene expression; Reporter gene; Cell biology; Gene; Chemistry; Biology; Molecular biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000161286,0.0001220745,0.000123483,0.00002439064,0.00008219996,0.00003621075,0.00008460697,0.00008385441,0.00001607533],"category_scores_gemma":[0.00005956841,0.00008385874,0.00003275735,0.00009116189,0.00004638069,0.00001908317,0.0001419673,0.00005598907,0.00001226818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003974238,"about_ca_system_score_gemma":0.00001915575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001457918,"about_ca_topic_score_gemma":0.00001363173,"domain_scores_codex":[0.9992062,0.00006745118,0.0001395095,0.0002193422,0.0001052974,0.0002621697],"domain_scores_gemma":[0.999604,0.000009620944,0.00004500446,0.0002429471,0.00002024402,0.00007819883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006944719,0.0001222274,0.004015211,0.00001421506,0.000004653659,0.000003126135,0.0008283581,2.317864e-7,0.992578,0.00003836614,0.001879258,0.0004469119],"study_design_scores_gemma":[0.0003931564,0.00008651239,0.02552576,0.00003082985,0.00001869782,0.00002760745,0.0003232871,4.511239e-7,0.9533022,0.00005467712,0.02006689,0.0001699457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929402,0.005708458,0.0001290458,0.0004364256,0.00006740554,0.0003389504,0.00002307048,0.000006720608,0.0003496822],"genre_scores_gemma":[0.9968861,0.0001564236,0.001619947,0.0004921326,0.0003450016,0.0001026492,0.00005037784,0.00001355675,0.0003338442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03927581,"threshold_uncertainty_score":0.341966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561565968994587,"score_gpt":0.2817153591256916,"score_spread":0.2560996994357457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}