{"id":"W2019954233","doi":"10.1371/journal.pone.0100179","title":"Cholinergic Signaling Exerts Protective Effects in Models of Sympathetic Hyperactivity-Induced Cardiac Dysfunction","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Fogarty International Center; National Institutes of Health; Universidade Federal de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Heart and Stroke Foundation of Canada","keywords":"Cholinergic; Pyridostigmine; Endocrinology; Internal medicine; Pyridostigmine Bromide; Adrenergic; Acetylcholine; Autonomic nervous system; Parasympathetic nervous system; Cholinergic neuron; Sympathetic nervous system; Stimulation; Medicine; Biology; Receptor; Heart rate; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004106369,0.0007919272,0.000951454,0.0006137424,0.0003223354,0.0005074791,0.0005327622,0.0006186049,0.001654516],"category_scores_gemma":[0.0002659596,0.0002996555,0.0005079855,0.0002513679,0.0005139599,0.0005028354,0.0004213774,0.002198268,0.0003207169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003154796,"about_ca_system_score_gemma":0.0003931612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004974204,"about_ca_topic_score_gemma":0.001069698,"domain_scores_codex":[0.999643,0.00006007047,0.00005230084,0.00007744526,0.0000706453,0.00009648179],"domain_scores_gemma":[0.999619,0.00003045986,0.0001158432,0.00004117266,0.00003350332,0.000160055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002731484,0.0006927656,0.0004954732,0.000143762,0.000045369,0.0001718231,0.00005180182,0.00007073159,0.9921854,0.0001170434,0.0001126518,0.003181737],"study_design_scores_gemma":[0.0007192708,0.01512038,0.02131033,0.0001444549,0.0003544153,0.0007403308,0.0003162597,0.001724688,0.9553519,0.000305272,0.003871591,0.00004110469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915638,0.004708838,0.001388593,0.0003118625,0.0001857585,0.00007512346,0.0003069977,0.0001275776,0.001331269],"genre_scores_gemma":[0.9892323,0.004803161,0.001425012,0.0002190901,0.00008480319,0.0002140316,0.0007356746,0.00003995518,0.003246075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654516,"threshold_uncertainty_score":0.005534887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162802597897859,"score_gpt":0.2231872252780742,"score_spread":0.2015591992990956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}