{"id":"W2019983949","doi":"10.1038/embor.2008.33","title":"Substrate‐induced DNA strand misalignment during catalytic cycling by DNA polymerase λ","year":2008,"lang":"en","type":"article","venue":"EMBO Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Chemistry; National Institute of Environmental Health Sciences; York University; Philip Morris International; National Institutes of Health; National Science Foundation","keywords":"DNA polymerase; Polymerase; Primer (cosmetics); Biology; Coding strand; DNA; Mutagenesis; DNA clamp; Base pair; Genetics; Mutant; Cell biology; Gene; Biochemistry; Chemistry; Polymerase chain reaction; Reverse transcriptase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005269412,0.0002873468,0.0002784198,0.0001890505,0.0003647856,0.0007649073,0.0005391252,0.0003744255,0.002469939],"category_scores_gemma":[0.001171398,0.0004451893,0.0001572991,0.000194346,0.0004420903,0.0008043128,0.0004960244,0.0006561858,0.0005763535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006699548,"about_ca_system_score_gemma":0.0004667864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000578667,"about_ca_topic_score_gemma":0.0006405117,"domain_scores_codex":[0.9997993,0.00002188976,0.00001419416,0.00005524965,0.000055843,0.00005350498],"domain_scores_gemma":[0.9995029,0.0001790465,0.0001156828,0.00007329819,0.00004648948,0.00008257973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008808589,0.00006039545,0.001418458,0.00009216947,0.00001982811,0.0004248743,0.0001787434,0.0009663992,0.9868588,0.001382773,0.0002495637,0.007467011],"study_design_scores_gemma":[0.00002913536,0.0001688694,0.003388368,0.000008495619,0.00001126231,0.000292091,0.00009448925,0.004597699,0.9901182,0.0004624744,0.0008105463,0.00001837428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964258,0.0004724174,0.001958666,0.00007433809,0.00003586869,0.000007802465,0.00002893184,0.00007837184,0.0009178312],"genre_scores_gemma":[0.9989649,0.0001131408,0.0002549042,0.00001586003,0.000005117404,0.000004469289,0.00004147848,0.00001734471,0.0005828135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002469939,"threshold_uncertainty_score":0.008262753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01061423110253252,"score_gpt":0.2275932431794549,"score_spread":0.2169790120769224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}