{"id":"W2019992046","doi":"10.4155/bio.13.339","title":"Isr: Background, Evolution and Implementation, with Specific Consideration for Ligand-Binding Assays","year":2014,"lang":"en","type":"review","venue":"Bioanalysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Agency (philosophy); Christian ministry; Regulatory science; Guideline; Political science; Regulatory agency; Interim; Public administration; Business; Public relations; Medicine; Law; Sociology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01202467,0.00130897,0.00135502,0.004145496,0.0004488929,0.003036612,0.002313888,0.00252619,0.002274731],"category_scores_gemma":[0.007321666,0.0007018332,0.001098339,0.003153317,0.001797234,0.003632673,0.00164214,0.003614352,0.002266694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002250372,"about_ca_system_score_gemma":0.005437779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00281438,"about_ca_topic_score_gemma":0.002367177,"domain_scores_codex":[0.99436,0.001363239,0.0006620394,0.000891522,0.002399277,0.0003238462],"domain_scores_gemma":[0.9940492,0.002620889,0.000783356,0.0002441854,0.002113575,0.0001887547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007431445,0.0001212039,0.000630729,0.01936658,0.00006291174,0.000286863,0.0003418938,0.0007250495,0.007616323,0.0232516,0.01387652,0.933646],"study_design_scores_gemma":[0.000007552832,0.0002169891,0.000784829,0.004246014,0.0000608614,0.0009876976,0.0001724044,0.0002058954,0.004907481,0.003027812,0.9853379,0.00004447139],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009155413,0.9824593,0.004446652,0.003104181,0.000574722,0.0000799543,0.00008269861,0.00005111402,0.008285789],"genre_scores_gemma":[0.006368368,0.979471,0.007540889,0.001838634,0.0006172109,0.00008955317,0.0001714941,0.0000281869,0.003874711],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01202467,"threshold_uncertainty_score":0.06359327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06367978857397234,"score_gpt":0.370916347293908,"score_spread":0.3072365587199357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}