{"id":"W2019992046","doi":"10.4155/bio.13.339","title":"Isr: Background, Evolution and Implementation, with Specific Consideration for Ligand-Binding Assays","year":2014,"lang":"en","type":"review","venue":"Bioanalysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Agency (philosophy); Christian ministry; Regulatory science; Guideline; Political science; Regulatory agency; Interim; Public administration; Business; Public relations; Medicine; Law; Sociology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009226866,0.000425141,0.001642768,0.0003766582,0.0003546102,0.0001101821,0.0001384053,0.0005746308,0.0002991917],"category_scores_gemma":[0.00004599536,0.0002879825,0.0004655478,0.0004259462,0.0002340891,0.00007511189,0.00004990007,0.0002372404,0.00005734988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001541175,"about_ca_system_score_gemma":0.0001082991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002578719,"about_ca_topic_score_gemma":0.0001051653,"domain_scores_codex":[0.9977428,0.0004252509,0.0007382431,0.0006670393,0.00006088944,0.0003658058],"domain_scores_gemma":[0.9983194,0.0006146286,0.0005324997,0.0003334068,0.0001563052,0.00004370798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003198468,0.00004580407,0.0001233667,0.002452623,0.003216188,0.000001450614,0.0000213997,1.039221e-7,0.0001626084,0.006557442,0.003916999,0.98347],"study_design_scores_gemma":[0.0005764621,0.0001762377,0.00001465938,0.0005883217,0.005969392,0.00004244542,0.0001569798,0.000003518866,0.0001219454,0.0001410152,0.9918088,0.0004002706],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001930911,0.9816353,0.01688715,0.0001242598,0.0002155461,0.0007265344,0.0002367135,0.00003615945,0.0001190306],"genre_scores_gemma":[0.0003812207,0.9921426,0.005107651,0.0000519883,0.000128192,0.0001295725,0.001061445,0.00003867612,0.0009586716],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9878917,"threshold_uncertainty_score":0.9999572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06367978857397234,"score_gpt":0.370916347293908,"score_spread":0.3072365587199357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}