{"id":"W2020001477","doi":"10.1016/j.ajpath.2010.09.044","title":"Activation-Induced Cytidine Deaminase and Aberrant Germinal Center Selection in the Development of Humoral Autoimmunities","year":2011,"lang":"en","type":"review","venue":"American Journal Of Pathology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; Canada Research Chairs","keywords":"Cytidine deaminase; Germinal center; Activation-induced (cytidine) deaminase; Biology; Cytidine; Selection (genetic algorithm); Immunology; Genetics; Virology; Somatic hypermutation; Antibody; Enzyme; Computer science; Biochemistry; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006921653,0.000917692,0.001142392,0.001152516,0.0002289118,0.000954362,0.001044249,0.001327455,0.001522914],"category_scores_gemma":[0.0005094272,0.0003282464,0.0002433013,0.001354243,0.0006339122,0.001445583,0.000698921,0.001786434,0.00184187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000655547,"about_ca_system_score_gemma":0.0009093561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005837117,"about_ca_topic_score_gemma":0.001138867,"domain_scores_codex":[0.9998467,0.000021412,0.00002652135,0.00003099614,0.00005577927,0.00001852976],"domain_scores_gemma":[0.9996959,0.00009830955,0.00006499662,0.00001141854,0.00008615146,0.00004326229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000198529,0.00008346956,0.0003946523,0.007541638,0.00006482347,0.000630621,0.0000409528,0.0003843776,0.005163389,0.003966319,0.03217182,0.9493596],"study_design_scores_gemma":[0.00004915426,0.0001101619,0.001979172,0.001402213,0.0001159738,0.004753595,0.00006761341,0.000184499,0.002161219,0.002659235,0.9864884,0.0000287514],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002294932,0.998453,0.0002107919,0.0002462946,0.0003174947,0.000003018314,0.000007615743,0.000006176357,0.0005261314],"genre_scores_gemma":[0.00134341,0.9971173,0.0002556559,0.0001769234,0.0004592426,0.000005342242,0.0000264797,0.00000135131,0.0006143327],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001522914,"threshold_uncertainty_score":0.005094707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04895808311038883,"score_gpt":0.3104482705015806,"score_spread":0.2614901873911918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}