{"id":"W2020003713","doi":"10.1111/bcpt.12071","title":"Enantiomer Selective Glucuronidation of the Non‐Steroidal Pure Anti‐Androgen Bicalutamide by Human Liver and Kidney: Role of the Human <scp>UDP</scp>‐Glucuronosyltransferase (<scp>UGT</scp>)1A9 Enzyme","year":2013,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Bicalutamide; Glucuronidation; Chemistry; Microsome; Glucuronosyltransferase; UGT2B7; Enantiomer; Pharmacology; Enzyme; Biochemistry; Internal medicine; Androgen receptor; Prostate cancer; Medicine; Stereochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526536,0.000264925,0.0002733657,0.0001752133,0.0001154424,0.0002788098,0.0001063033,0.0002098021,0.00088246],"category_scores_gemma":[0.0001904337,0.0001644452,0.0002876275,0.0002319245,0.000151047,0.0001475337,0.0001118998,0.0001708353,0.0003393717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379146,"about_ca_system_score_gemma":0.0003086757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003414611,"about_ca_topic_score_gemma":0.00382933,"domain_scores_codex":[0.9998423,0.00004952117,0.000009521249,0.00004035202,0.00003002958,0.00002820469],"domain_scores_gemma":[0.9999425,0.000009972496,0.00001486437,0.000008334955,0.00001475709,0.000009460507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001421542,0.00003793797,0.002893109,0.0001166257,0.00005646383,0.0001909374,0.00007621582,0.0001548147,0.987752,0.00009973747,0.0000988515,0.007101701],"study_design_scores_gemma":[0.00004504151,0.0004792996,0.03381579,0.000009265113,0.0001138558,0.001271075,0.00007699255,0.001544022,0.9596494,0.00005432136,0.002921182,0.00001978362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884169,0.006553834,0.003298589,0.00008938598,0.00001853846,0.00002742225,0.0004175235,0.0000586712,0.001119295],"genre_scores_gemma":[0.9935508,0.001595515,0.00209627,0.00004703497,0.000008004326,0.00001182748,0.000780739,0.00001805012,0.001891715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003414611,"threshold_uncertainty_score":0.006789446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04200298300861147,"score_gpt":0.3787265330817431,"score_spread":0.3367235500731316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}