{"id":"W2020016210","doi":"10.1016/j.molcel.2011.04.005","title":"Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells","year":2011,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":625,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; University of Pennsylvania","keywords":"Biology; Embryonic stem cell; Gene; Cell biology; Stem cell; Gene expression; Genome; Regulation of gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001875634,0.0001646058,0.0001611812,0.00007287732,0.00002959975,0.000009483029,0.0001240902,0.0001856432,0.00001589368],"category_scores_gemma":[0.000008230695,0.0001720779,0.00005869558,0.00007686555,0.00005031592,0.000005221746,0.0001036998,0.00007021426,0.000003952715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001281648,"about_ca_system_score_gemma":0.00002311027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002541289,"about_ca_topic_score_gemma":0.000006349119,"domain_scores_codex":[0.998915,0.0001064551,0.0002727795,0.0003703916,0.0001326544,0.0002027651],"domain_scores_gemma":[0.9993334,0.000008145319,0.0001458497,0.0003804814,0.00004725203,0.00008486801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004640329,0.00009525647,0.002467314,0.0000333608,0.000007681351,0.000003862878,0.0001053669,0.0002316947,0.9966675,0.000002869757,0.00002861833,0.0003100678],"study_design_scores_gemma":[0.0005740005,0.000178465,0.00211551,0.000007662646,0.00001144253,4.310445e-7,0.00002604973,0.000113995,0.995551,0.00006757223,0.001169051,0.0001847887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843284,0.005574858,0.008845871,0.000007207354,0.00003662585,0.0002250249,0.00001920625,0.000006594125,0.0009562293],"genre_scores_gemma":[0.9966438,0.0004815689,0.001960255,0.00003868878,0.00001386294,0.00001175614,0.00009554562,0.00003346624,0.0007211042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01231537,"threshold_uncertainty_score":0.7017134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007868205985788402,"score_gpt":0.193723213323455,"score_spread":0.1858550073376666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}