{"id":"W2020039080","doi":"10.1074/jbc.m706163200","title":"Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Toronto; McMaster University","funders":"","keywords":"Isomerase; Biosynthesis; Enzyme; Function (biology); Biochemistry; Antibiotics; Chemistry; Lipopolysaccharide; Biology; Microbiology; Cell biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005759132,0.0001523451,0.0003765172,0.00003589524,0.00008580504,0.00002762967,0.00009394537,0.0002540545,0.0001398321],"category_scores_gemma":[0.000982802,0.0001010318,0.0001003261,0.00005204367,0.0002309065,0.0001106896,0.00002889325,0.0001230614,1.735977e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001835758,"about_ca_system_score_gemma":0.00002731441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001884549,"about_ca_topic_score_gemma":7.22921e-7,"domain_scores_codex":[0.9989066,0.00001726497,0.0004810617,0.000219353,0.0001275092,0.0002482127],"domain_scores_gemma":[0.9986656,0.000588429,0.0003069691,0.00008315969,0.0002158691,0.0001399952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001089639,0.00003389519,0.00133892,0.0002188934,0.00002187953,0.000003174147,0.00001970103,0.000001664383,0.9939206,0.0001006223,0.0001238895,0.0031271],"study_design_scores_gemma":[0.0006424855,0.0006888847,0.002846098,0.0000649106,0.0000738717,0.00009859481,0.0001137223,0.00003136863,0.9911929,0.003790637,0.0003354507,0.0001210204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862651,0.001781311,0.01119853,0.00012038,0.0003292478,0.000117138,0.0001595296,0.0000103773,0.00001837745],"genre_scores_gemma":[0.9891658,0.00006847455,0.0101941,0.00009161483,0.0004531635,9.93513e-7,0.000005005904,0.00000845455,0.00001242013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003690014,"threshold_uncertainty_score":0.4119956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558220230574294,"score_gpt":0.2601757289245636,"score_spread":0.2445935266188207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}