{"id":"W2020044564","doi":"10.1006/dbio.2000.9992","title":"Ligand-Induced Signaling in the Absence of Furin Processing of Notch1","year":2001,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; National Institutes of Health; Cancer Research Institute","keywords":"Furin; Biology; Notch signaling pathway; Cell biology; Signal transduction; Ligand (biochemistry); Receptor; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002768789,0.0001751933,0.0002004524,0.000221425,0.0002473946,0.0006973349,0.0003467159,0.0003170662,0.00185047],"category_scores_gemma":[0.0003280099,0.0002184963,0.000166638,0.0001774498,0.0002820849,0.0003540471,0.0002772369,0.0007231919,0.0005542091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001031397,"about_ca_system_score_gemma":0.0005936233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001861684,"about_ca_topic_score_gemma":0.002867206,"domain_scores_codex":[0.9997033,0.00005882682,0.00003220961,0.00003870007,0.00008870734,0.00007823506],"domain_scores_gemma":[0.9997601,0.00005755945,0.00003838593,0.00004224216,0.00003067119,0.00007114745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002421018,0.0000209765,0.0001200551,0.00001835937,0.000002618898,0.00006792357,0.000009757101,0.0000793814,0.9984797,0.0004711039,0.00005578509,0.0004322876],"study_design_scores_gemma":[0.00002259093,0.00004014186,0.002656821,0.00000555313,0.000004976522,0.0001744638,0.00002678082,0.001262789,0.9944555,0.0001173561,0.001226705,0.000006238589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950171,0.0006503211,0.0009651483,0.0001674522,0.00003880374,0.00001293705,0.0004966775,0.00004499347,0.002606519],"genre_scores_gemma":[0.9944069,0.0002265549,0.0008136505,0.00005866261,0.000006283364,0.00001255138,0.000863223,0.00001732193,0.003594796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001861684,"threshold_uncertainty_score":0.007483363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697889271986127,"score_gpt":0.2658803497226793,"score_spread":0.248901457002818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}