{"id":"W2020046808","doi":"10.1152/ajpcell.00208.2007","title":"Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro","year":2007,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Veterans Affairs; National Institutes of Health; National Center for Research Resources; American Diabetes Association","keywords":"Islet; Amyloid (mycology); Chemistry; In vivo; Glycosaminoglycan; Internal medicine; Heparan sulfate; Genetically modified mouse; Endocrinology; Glycosylation; In vitro; Biochemistry; Transgene; Insulin; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960441,0.0006078436,0.0006709606,0.0002231034,0.0001188702,0.000327147,0.0003867438,0.0003609262,0.001187352],"category_scores_gemma":[0.0002444364,0.0002433384,0.0003987575,0.0002555967,0.0003852726,0.0002368578,0.0001907881,0.0007758019,0.0003996346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141701,"about_ca_system_score_gemma":0.0002538861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009755754,"about_ca_topic_score_gemma":0.0007054913,"domain_scores_codex":[0.9996829,0.00006912604,0.00003885964,0.00004549065,0.000089786,0.00007394447],"domain_scores_gemma":[0.9997972,0.00004879876,0.00004124469,0.00002391512,0.00001955782,0.00006932554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006467091,0.0001079892,0.0001194249,0.00003095475,0.00001574311,0.00004583479,0.00001111216,0.00009758052,0.9977158,0.00004171802,0.00003416694,0.00113305],"study_design_scores_gemma":[0.0000448852,0.001261381,0.002165831,0.000003725153,0.00001922892,0.0001689537,0.00001243655,0.0007253218,0.9946696,0.00002258078,0.0009017772,0.000004126774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931642,0.003240749,0.001341504,0.00008428962,0.00005571836,0.00002435599,0.000350193,0.0001073632,0.001631525],"genre_scores_gemma":[0.9920622,0.001821521,0.002656422,0.00005969913,0.00002386705,0.00005637509,0.001061911,0.00003508333,0.002222972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187352,"threshold_uncertainty_score":0.003972113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006694439304079969,"score_gpt":0.2231560137320872,"score_spread":0.2164615744280073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}