{"id":"W2020046808","doi":"10.1152/ajpcell.00208.2007","title":"Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro","year":2007,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Veterans Affairs; National Institutes of Health; National Center for Research Resources; American Diabetes Association","keywords":"Islet; Amyloid (mycology); Chemistry; In vivo; Glycosaminoglycan; Internal medicine; Heparan sulfate; Genetically modified mouse; Endocrinology; Glycosylation; In vitro; Biochemistry; Transgene; Insulin; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003925043,0.0001778136,0.0007846115,0.0004853395,0.00002706641,0.000003196345,0.00004324468,0.00007969479,0.00001205185],"category_scores_gemma":[0.000186826,0.0001364628,0.00004855146,0.0003957085,0.0004614132,0.000174566,0.00002477233,0.000270159,9.045497e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007427569,"about_ca_system_score_gemma":0.000058326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000159729,"about_ca_topic_score_gemma":0.00001513858,"domain_scores_codex":[0.9985157,0.0001798505,0.0006949439,0.0002163224,0.0001294639,0.000263772],"domain_scores_gemma":[0.9985092,0.0003083405,0.0007926885,0.0001436012,0.0001435777,0.0001026099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01105107,0.0002343741,0.000417803,0.0001305216,0.0000268839,0.00001144265,0.0003279785,0.00004841237,0.9829237,0.00001281307,0.00001314756,0.004801888],"study_design_scores_gemma":[0.003042514,0.00284871,0.1602764,0.0002336466,0.00004202525,0.00007935039,0.000950558,0.0002627429,0.8318745,0.0002530187,0.00002240346,0.0001140884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990851,0.00009874877,0.00006865971,0.0002546293,0.00002693898,0.0002712884,0.000005355056,0.000007389294,0.0001818799],"genre_scores_gemma":[0.9977091,0.00008955062,0.001906667,0.0001547892,0.00008305111,0.00001154851,0.00002283199,0.0000139513,0.00000849917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1598586,"threshold_uncertainty_score":0.556479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006694439304079969,"score_gpt":0.2231560137320872,"score_spread":0.2164615744280073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}