{"id":"W2020054949","doi":"10.1371/journal.pone.0011260","title":"Efficient Generation of Germ Line Transmitting Chimeras from C57BL/6N ES Cells by Aggregation with Outbred Host Embryos","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children; Toronto Centre for Phenogenomics","funders":"National Institute on Drug Abuse; National Institutes of Health; Genome Prairie; Regeneron Pharmaceuticals; Genome Canada","keywords":"Germline; Chimera (genetics); Embryonic stem cell; Biology; Mutagenesis; Mutant; Computational biology; Functional genomics; Genome; Genetics; Stem cell; Somatic cell; Genomics; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001562512,0.0001444892,0.0001825827,0.0000433281,0.00007110952,0.00002387643,0.000159698,0.0001526826,0.00004691606],"category_scores_gemma":[0.00004345023,0.0001286738,0.00004604075,0.00008695301,0.00007653565,0.00000332891,0.00003807208,0.0001689605,0.0000132097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007934295,"about_ca_system_score_gemma":0.00005754951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007689842,"about_ca_topic_score_gemma":0.00008183359,"domain_scores_codex":[0.9987541,0.0000543134,0.0002412719,0.0003554266,0.0003784358,0.0002164145],"domain_scores_gemma":[0.9992563,0.00002058262,0.000135365,0.0003307539,0.0001725452,0.00008445883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008861255,0.0007216979,0.0006411053,0.00004316372,0.0001396101,0.000001187167,0.00008485938,0.0001851909,0.9974976,0.000002011398,0.00008922648,0.0005057575],"study_design_scores_gemma":[0.0006962722,0.0002593655,0.0004751167,0.000044203,0.00005691019,6.309169e-7,0.00001467835,0.0133633,0.9848432,0.000001194849,0.00009526825,0.000149878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973533,0.0003370511,0.001461862,0.0001522035,0.00004684761,0.0003696819,0.0001343831,0.00001321044,0.0001315058],"genre_scores_gemma":[0.9945627,0.00008034788,0.00396846,0.00004291916,0.0002788892,0.00002437817,0.0005745306,0.00002947394,0.0004383031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01317811,"threshold_uncertainty_score":0.5247166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987125002219665,"score_gpt":0.2252389081630968,"score_spread":0.2053676581409002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}