{"id":"W2020054949","doi":"10.1371/journal.pone.0011260","title":"Efficient Generation of Germ Line Transmitting Chimeras from C57BL/6N ES Cells by Aggregation with Outbred Host Embryos","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children; Toronto Centre for Phenogenomics","funders":"National Institute on Drug Abuse; National Institutes of Health; Genome Prairie; Regeneron Pharmaceuticals; Genome Canada","keywords":"Germline; Chimera (genetics); Embryonic stem cell; Biology; Mutagenesis; Mutant; Computational biology; Functional genomics; Genome; Genetics; Stem cell; Somatic cell; Genomics; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001047164,0.0005456299,0.0004906586,0.0008842305,0.0004842361,0.0006180957,0.0007992096,0.0006087834,0.002849353],"category_scores_gemma":[0.0003580309,0.0004648833,0.000464811,0.0003550339,0.0003803819,0.0003184656,0.0009849797,0.001706501,0.001804648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003372777,"about_ca_system_score_gemma":0.0003764954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005082384,"about_ca_topic_score_gemma":0.001256398,"domain_scores_codex":[0.9994338,0.0000772466,0.00008124384,0.0001107836,0.0002385449,0.00005830267],"domain_scores_gemma":[0.9995327,0.0000880689,0.0001226441,0.0001125555,0.00003873161,0.0001053377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003988169,0.00001955518,0.0001375911,0.00003375545,0.000007369144,0.00007770259,0.00003857872,0.0001034216,0.9974016,0.0004903942,0.0001644205,0.001485727],"study_design_scores_gemma":[0.00002213859,0.0000888646,0.002115925,0.00002246737,0.00002860906,0.0005268753,0.00002941228,0.001420074,0.9832496,0.0001480827,0.01233602,0.00001193602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.808646,0.002051961,0.1623209,0.0005595463,0.0003091106,0.001250458,0.007003287,0.00256063,0.01529812],"genre_scores_gemma":[0.7873214,0.004775668,0.1628451,0.0003931095,0.00007505367,0.001027883,0.008756177,0.001994514,0.03281103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002849353,"threshold_uncertainty_score":0.009531975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987125002219665,"score_gpt":0.2252389081630968,"score_spread":0.2053676581409002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}