{"id":"W2020066813","doi":"10.1111/febs.12272","title":"Structure–function relationship and biogenesis regulation of the human telomerase holoenzyme","year":2013,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Telomerase; Telomere; Telomerase reverse transcriptase; Telomerase RNA component; Biogenesis; Biology; Reverse transcriptase; Cell biology; RNA; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003286281,0.0003493383,0.001048987,0.0004266914,0.0004358801,0.00006741319,0.0001803246,0.0003903795,0.0004371835],"category_scores_gemma":[0.0002424429,0.0002053497,0.0004174855,0.0005263703,0.0001809856,0.0001588753,0.00005558357,0.0008338914,0.00001604463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267403,"about_ca_system_score_gemma":0.000273344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002493963,"about_ca_topic_score_gemma":0.00000698438,"domain_scores_codex":[0.9977623,0.0003075179,0.000932382,0.0002827806,0.000473793,0.0002412323],"domain_scores_gemma":[0.9979003,0.0001425307,0.001061278,0.0004764967,0.0002284648,0.0001909386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003276102,0.00007914982,0.01360524,0.007009262,0.0003940429,0.00001411512,0.0001381083,0.000001827414,0.001205035,0.00062281,0.00645875,0.9704389],"study_design_scores_gemma":[0.001099905,0.0002951301,0.2322335,0.01495825,0.004403378,0.005013752,0.0000635192,0.000006916095,0.000252626,0.001482041,0.739621,0.0005699921],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02691722,0.9714243,0.00004721816,0.000111886,0.0006256581,0.0006957943,0.00003945305,0.00002375941,0.0001147487],"genre_scores_gemma":[0.02463056,0.972048,0.0003958974,0.00006147898,0.0008950446,0.00001195054,0.00008793647,0.00006579576,0.001803299],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9698689,"threshold_uncertainty_score":0.8373918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06576561881235787,"score_gpt":0.3220132610991248,"score_spread":0.2562476422867669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}