{"id":"W2020083160","doi":"10.1093/nar/gkq030","title":"Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex","year":2010,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chromatin immunoprecipitation; Biology; Phosphorylation; Chromatin remodeling; Transcription factor; Chromatin structure remodeling (RSC) complex; SWI/SNF; Cell biology; Promoter; Molecular biology; Chromatin; Transcription (linguistics); Immunoprecipitation; Serine; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000118397,0.0003467303,0.0001877102,0.0001563066,0.0001622485,0.0001969316,0.0001619151,0.00009488865,0.001587965],"category_scores_gemma":[0.00009390283,0.0001668296,0.0002356138,0.00009822175,0.0002341492,0.0001150169,0.0001947567,0.0003055551,0.0005958987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004434112,"about_ca_system_score_gemma":0.0002162232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004786879,"about_ca_topic_score_gemma":0.001456311,"domain_scores_codex":[0.9999161,0.000008784725,0.000005493158,0.00002737933,0.00002163404,0.00002070227],"domain_scores_gemma":[0.9999292,0.00001025003,0.00002558884,0.000007268955,0.00000712609,0.00002051235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009974628,0.000009767964,0.0002544214,0.00002481056,0.000003445928,0.0000168163,0.000006253125,0.00003484053,0.9986852,0.00005314649,0.0000276484,0.0007838211],"study_design_scores_gemma":[0.00001183936,0.00007674755,0.007119673,0.000004788404,0.000006090371,0.0001001817,0.00001088147,0.000315128,0.9903527,0.00006013939,0.001939346,0.000002546599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914889,0.00206305,0.004313415,0.00007721649,0.00001832587,0.00001912836,0.0003697473,0.000106377,0.001543903],"genre_scores_gemma":[0.9923043,0.001108448,0.003486996,0.00003275294,0.000009489419,0.00002918086,0.0008627176,0.00001977678,0.002146398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001587965,"threshold_uncertainty_score":0.005312264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05778082654211322,"score_gpt":0.3387186310439499,"score_spread":0.2809378045018367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}