{"id":"W2020138546","doi":"10.1038/cmi.2012.37","title":"A novel T cell-based vaccine capable of stimulating long-term functional CTL memory against B16 melanoma via CD40L signaling","year":2012,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"CTL*; Melanoma; CD40; Term (time); Immunology; Medicine; Cancer research; Biology; Virology; Immune system; Cytotoxic T cell; Genetics; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004524304,0.0002698307,0.0005185194,0.0002859466,0.0001129564,0.00001266125,0.0001215467,0.0002466958,0.001091002],"category_scores_gemma":[0.00005349336,0.0002618028,0.0001948051,0.0002206236,0.0001457817,0.00006709898,0.0001120808,0.0004088294,0.00002019925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008296521,"about_ca_system_score_gemma":0.0001364764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005935622,"about_ca_topic_score_gemma":0.00000193895,"domain_scores_codex":[0.9981552,0.0001231975,0.000428958,0.0003492055,0.0003141092,0.0006293209],"domain_scores_gemma":[0.9988821,0.0001299735,0.0001464331,0.0004773097,0.0001822486,0.0001819652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006346764,0.0004506528,0.01258631,0.0001888729,0.000294758,0.00009730474,0.0001545925,0.0004135531,0.9819091,0.00004145925,0.00001122986,0.003217489],"study_design_scores_gemma":[0.005410185,0.0005013428,0.007755848,0.00007767117,0.0001663739,0.0001003221,0.00006300631,0.001325281,0.9841119,0.000009786886,0.0002417513,0.0002365213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9189397,0.01162502,0.06712402,0.0001058632,0.0002204708,0.000450034,0.000004761492,0.00003999559,0.001490206],"genre_scores_gemma":[0.997334,0.00004620431,0.001126764,0.0002771002,0.0001275643,0.00002556439,0.0002005814,0.00006660356,0.0007956111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07839438,"threshold_uncertainty_score":0.9999834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01845580264347052,"score_gpt":0.2565204328658132,"score_spread":0.2380646302223426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}