{"id":"W2020158018","doi":"10.1038/mt.2013.238","title":"Immunogenic HSV-mediated Oncolysis Shapes the Antitumor Immune Response and Contributes to Therapeutic Efficacy","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"McMaster University; Canadian Breast Cancer Research Alliance; Cancer Research Society","keywords":"Oncolytic virus; Herpes simplex virus; Biology; Virus; Virology; Immune system; Antigen; CD8; Viral replication; Context (archaeology); Cytotoxic T cell; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002948832,0.0002358687,0.0003406844,0.0002237276,0.0001208996,0.0008528316,0.0001608505,0.0003707717,0.001296507],"category_scores_gemma":[0.0003075891,0.0001648629,0.0001488655,0.0001031432,0.0003155298,0.0003903976,0.0003595093,0.0006815314,0.0004748086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004796617,"about_ca_system_score_gemma":0.0003217846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001094542,"about_ca_topic_score_gemma":0.0001124013,"domain_scores_codex":[0.9997597,0.00005194594,0.00001601106,0.00003659374,0.00006857166,0.0000671837],"domain_scores_gemma":[0.9998494,0.00003193663,0.00003408531,0.00002062212,0.00002307701,0.00004078319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002039805,0.00004351213,0.0007061641,0.00004306413,0.000003683967,0.00003634877,0.00002677385,0.0004727187,0.9905172,0.001014765,0.0000758052,0.006856062],"study_design_scores_gemma":[0.00005069104,0.0008082931,0.01420381,0.00002402696,0.00004494019,0.0005110436,0.0001091504,0.007459568,0.968514,0.001454263,0.006805715,0.0000144848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871823,0.002984145,0.004945968,0.0002074432,0.00003912083,0.00003974761,0.0001028694,0.0001102851,0.004388135],"genre_scores_gemma":[0.9969637,0.000685136,0.001322431,0.00004865851,0.00001689759,0.00001517759,0.0000395149,0.00001846756,0.0008900681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296507,"threshold_uncertainty_score":0.004337311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215865977169847,"score_gpt":0.2830090112866253,"score_spread":0.2708503515149269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}