{"id":"W2020158668","doi":"10.1042/bj20021905","title":"Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity","year":2003,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Associazione Italiana per la Ricerca sul Cancro; Canadian Institutes of Health Research; Ministero dell’Istruzione, dell’Università e della Ricerca; Giovanni Armenise-Harvard Foundation","keywords":"Phosphorylation; Proto-oncogene tyrosine-protein kinase Src; LYN; Phosphopeptide; SH2 domain; Biochemistry; Tyrosine phosphorylation; Protein phosphorylation; Protein tyrosine phosphatase; Tyrosine; Tyrosine kinase; Tyrosine-protein kinase CSK; Biology; Kinase; Chemistry; MAP2K7; Protein kinase A; Cyclin-dependent kinase 2; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003068259,0.0002509088,0.0002542417,0.00006616218,0.0001240888,0.00003749297,0.0001387982,0.0002523671,0.00008476787],"category_scores_gemma":[0.0003048689,0.0002092224,0.0001216532,0.0002358053,0.0001921129,0.0000153724,0.00003420211,0.0002554179,0.000004489825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004856929,"about_ca_system_score_gemma":0.0001868006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000189685,"about_ca_topic_score_gemma":0.000001322919,"domain_scores_codex":[0.9985973,0.0001203673,0.0003787725,0.0003175146,0.0002949261,0.0002911378],"domain_scores_gemma":[0.9989006,0.00001711532,0.0003694975,0.0002583787,0.0002290037,0.0002253862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004252656,0.0002643284,0.001153141,0.00002936508,0.00007129667,0.00001034363,0.00001098345,0.000036423,0.9963205,0.00007995113,0.001026103,0.0005722888],"study_design_scores_gemma":[0.00181015,0.00037248,0.0005449586,0.0001574952,0.00005529083,0.0001770387,0.00001564744,0.0001165866,0.9952662,0.0001055122,0.001103152,0.0002754839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924471,0.00459358,0.002312689,0.00007259744,0.00004620255,0.00029885,0.00003259579,0.00001594931,0.0001803951],"genre_scores_gemma":[0.9986237,0.00006310546,0.0008320078,0.00003780943,0.00006134355,0.00001402414,0.0001684715,0.00003300771,0.0001664843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006176604,"threshold_uncertainty_score":0.8531842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006105033356086561,"score_gpt":0.2154510465781313,"score_spread":0.2093460132220448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}