{"id":"W2020191778","doi":"10.1371/journal.pone.0071761","title":"Mesenchymal Stromal (Stem) Cell Therapy Fails to Improve Outcomes in Experimental Severe Influenza","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; University Health Network; Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Advanced Research Projects Agency; U.S. Public Health Service; Defense Advanced Research Projects Agency","keywords":"Medicine; Mesenchymal stem cell; Immunology; Bronchoalveolar lavage; Oseltamivir; Cell therapy; Zanamivir; Inflammation; Stem cell; Lung; Internal medicine; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002550831,0.0003029697,0.0006796863,0.0002666553,0.00005919387,0.00009749409,0.0002825113,0.0001627723,0.003155197],"category_scores_gemma":[0.00006226463,0.0002444155,0.0001076711,0.0002961426,0.0000566896,0.0003111829,0.0001927811,0.0004310165,0.002213398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554732,"about_ca_system_score_gemma":0.0001263471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007012996,"about_ca_topic_score_gemma":0.00001558778,"domain_scores_codex":[0.9969034,0.0001065732,0.0004930581,0.0005391989,0.001169006,0.0007888244],"domain_scores_gemma":[0.9984407,0.0001488368,0.00006968198,0.0006192998,0.0001626093,0.0005588196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002140656,0.002885046,0.1752744,0.0001018248,0.0001117786,0.00004050824,0.0009135667,0.000001014053,0.8190146,0.00001299314,0.0002299336,0.001200212],"study_design_scores_gemma":[0.00410098,0.001973836,0.09436798,0.0001271484,0.00001822556,0.000004308953,0.001539221,0.0001369971,0.8972269,0.00001392103,0.0001770904,0.0003134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848976,0.0004930271,0.000001895894,0.000958643,0.00004940184,0.002957511,0.000008262584,0.00007589572,0.01055779],"genre_scores_gemma":[0.9853634,0.00001884418,0.001303704,0.001100304,0.0001211329,0.0005687753,0.000005707168,0.0000580533,0.01146003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08090647,"threshold_uncertainty_score":0.9985635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07948385296317331,"score_gpt":0.3156045307262834,"score_spread":0.23612067776311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}