{"id":"W2020206181","doi":"10.1002/ana.21363","title":"Rituximab in relapsing‐remitting multiple sclerosis: A 72‐week, open‐label, phase I trial","year":2008,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":530,"is_retracted":false,"has_abstract":true,"ca_institutions":"NeuroRx Research (Canada); McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Tolerability; Medicine; Multiple sclerosis; Relapsing remitting; Rituximab; Adverse effect; Open label; Internal medicine; Gastroenterology; Immunology; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001080008,0.0002569458,0.00110893,0.0003944235,0.0002013545,0.00001551539,0.0004573363,0.000204891,0.00007796015],"category_scores_gemma":[0.005718305,0.000238657,0.0001276845,0.000527679,0.0004991858,0.0002102178,0.0006230394,0.00070749,0.00004594527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000137723,"about_ca_system_score_gemma":0.0001784623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004498672,"about_ca_topic_score_gemma":0.0001024826,"domain_scores_codex":[0.9967262,0.0004407159,0.0008724908,0.0006324555,0.0004598251,0.0008683351],"domain_scores_gemma":[0.9977018,0.0009323246,0.0002647213,0.0005763235,0.0003103383,0.0002145003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5097275,0.05771889,0.06269456,0.0003699374,0.000593356,0.00177982,0.003348844,0.00003407704,0.2204359,0.0001274957,0.07335091,0.06981868],"study_design_scores_gemma":[0.7833311,0.02951452,0.1529816,0.0004611995,0.00005917559,0.000230386,0.0001244621,0.003016219,0.0163934,0.0001352315,0.01322353,0.0005291806],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850503,0.0008721247,0.00001168388,0.01079269,0.000251892,0.001498969,0.00002361631,0.00005042702,0.001448301],"genre_scores_gemma":[0.9920881,0.003186674,0.0004772869,0.003664528,0.0002252789,0.0001561823,0.00001450252,0.00004198426,0.0001454044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2736036,"threshold_uncertainty_score":0.9732149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4994950609362196,"score_gpt":0.4451126757696178,"score_spread":0.05438238516660188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}