{"id":"W2020206181","doi":"10.1002/ana.21363","title":"Rituximab in relapsing‐remitting multiple sclerosis: A 72‐week, open‐label, phase I trial","year":2008,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":530,"is_retracted":false,"has_abstract":true,"ca_institutions":"NeuroRx Research (Canada); McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Tolerability; Medicine; Multiple sclerosis; Relapsing remitting; Rituximab; Adverse effect; Open label; Internal medicine; Gastroenterology; Immunology; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001463957,0.00208944,0.003057558,0.0003744528,0.000644588,0.0008728972,0.00105253,0.002380775,0.003150543],"category_scores_gemma":[0.001067152,0.0006144134,0.001036227,0.0003933106,0.000969183,0.0009647664,0.0003054176,0.002936853,0.001258436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004784968,"about_ca_system_score_gemma":0.0006721821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005536635,"about_ca_topic_score_gemma":0.001153995,"domain_scores_codex":[0.999511,0.0002444451,0.00002284061,0.00008889595,0.00003949014,0.00009333023],"domain_scores_gemma":[0.9992995,0.000155236,0.000126386,0.00007192276,0.00003741723,0.0003095123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8561044,0.027304,0.001432363,0.0009282033,0.0009846963,0.0003577413,0.0002298968,0.0009398679,0.02342908,0.0001247729,0.00233142,0.08583359],"study_design_scores_gemma":[0.7881309,0.2051073,0.003486064,0.00005046885,0.0002186218,0.0002254963,0.00003363169,0.0004295788,0.001021539,0.00008769306,0.001182264,0.00002649645],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989046,0.008027707,0.0003428212,0.0004398059,0.0001543674,0.0006775138,0.000351927,0.0001457565,0.0008140252],"genre_scores_gemma":[0.9900393,0.003576257,0.001144535,0.0006775704,0.0003964377,0.001642343,0.0005685883,0.00003014928,0.001924769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003150543,"threshold_uncertainty_score":0.01053965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4994950609362196,"score_gpt":0.4451126757696178,"score_spread":0.05438238516660188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}