{"id":"W2020242913","doi":"10.1186/1471-2148-8-103","title":"Evolution of pharmacologic specificity in the pregnane X receptor","year":2008,"lang":"en","type":"article","venue":"BMC Evolutionary Biology","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medical Center, University of Pittsburgh; National Institutes of Health; Ministry of Education, Culture, Sports, Science and Technology; National Institute of General Medical Sciences; Research Organization of Information and Systems; University of Pittsburgh","keywords":"Pregnane X receptor; Biology; Ciona intestinalis; Ciona; Xenopus; Ligand (biochemistry); Pharmacophore; Nuclear receptor; Zebrafish; Receptor; Calcitriol receptor; Cell biology; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004099071,0.0001127661,0.0002696043,0.0001691566,0.0001229584,6.47702e-7,0.0001813198,0.0001154617,0.000251151],"category_scores_gemma":[0.0004984291,0.00006983749,0.00008850647,0.0004189089,0.0008213518,0.00003947651,0.00009116275,0.0002488126,0.00007235351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002864645,"about_ca_system_score_gemma":0.0002644765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009849799,"about_ca_topic_score_gemma":0.00002190601,"domain_scores_codex":[0.9985482,0.000417575,0.0002946435,0.000242865,0.0001957162,0.0003010624],"domain_scores_gemma":[0.999121,0.0003918071,0.00007856608,0.0002281543,0.0001404415,0.00004006041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002737489,0.0005943356,0.9327661,0.00006781654,0.00003181065,0.00002302954,0.000237129,0.0000212632,0.04200472,0.002109971,0.02173312,0.0001368895],"study_design_scores_gemma":[0.001055549,0.0006233315,0.9919832,0.00003688143,0.00001391657,0.0001834828,0.000368994,0.0001821663,0.0004875045,0.0005273717,0.004467342,0.00007025162],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862805,0.008231507,0.0003788222,0.0009458174,0.0001940809,0.0006536752,0.00002959868,0.00003259714,0.003253419],"genre_scores_gemma":[0.9966098,0.0009953286,0.001453918,0.00006720878,0.0002276775,0.00008691566,0.0000407115,0.000005613065,0.0005128229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05921704,"threshold_uncertainty_score":0.3026305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07118197008612122,"score_gpt":0.3413047213829691,"score_spread":0.2701227512968479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}