{"id":"W2020275122","doi":"10.1038/nature10798","title":"Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":659,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Japan Science and Technology Agency; Medical Research Council; Council for Science and Technology Policy; Oulun Yliopisto; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Agence Nationale de la Recherche; European Commission","keywords":"GPR120; Endocrinology; Adipose tissue; Internal medicine; Lipogenesis; Biology; Receptor; Insulin receptor; Adipogenesis; Free fatty acid receptor 1; Nutrient sensing; Energy homeostasis; Insulin resistance; Glucose homeostasis; Insulin; Obesity; Cell biology; Signal transduction; Medicine; G protein-coupled receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002524326,0.0009370606,0.0003619914,0.0008791672,0.0002472918,0.0005199525,0.0003542463,0.0009086598,0.00443895],"category_scores_gemma":[0.0002482528,0.0004465652,0.0007606575,0.0004701019,0.0006688126,0.00025727,0.0004385294,0.001379225,0.001003176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199756,"about_ca_system_score_gemma":0.0002554345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000710985,"about_ca_topic_score_gemma":0.0006325488,"domain_scores_codex":[0.9997357,0.00004994824,0.00003250888,0.00007899362,0.00005508746,0.00004781948],"domain_scores_gemma":[0.9997726,0.00003599266,0.00008290033,0.00005153725,0.00001013636,0.00004680774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001118167,0.0001327071,0.0007145582,0.00006858505,0.00005693236,0.001531386,0.00004261818,0.0002479093,0.990893,0.001105543,0.0006744979,0.003414097],"study_design_scores_gemma":[0.0009995882,0.002195302,0.03204336,0.0001072015,0.0007104445,0.03659192,0.0003860993,0.005190616,0.8910389,0.002991188,0.02764767,0.00009767927],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867791,0.001238872,0.005723907,0.0005801237,0.0001704947,0.00004679113,0.002639092,0.0004701341,0.002351507],"genre_scores_gemma":[0.9894606,0.001718502,0.002179994,0.000341072,0.00005577202,0.00006992131,0.001540537,0.0002051855,0.00442832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00443895,"threshold_uncertainty_score":0.01484972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006691838515754685,"score_gpt":0.2462264711184705,"score_spread":0.2395346326027158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}