{"id":"W2020275122","doi":"10.1038/nature10798","title":"Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":659,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Japan Science and Technology Agency; Medical Research Council; Council for Science and Technology Policy; Oulun Yliopisto; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Agence Nationale de la Recherche; European Commission","keywords":"GPR120; Endocrinology; Adipose tissue; Internal medicine; Lipogenesis; Biology; Receptor; Insulin receptor; Adipogenesis; Free fatty acid receptor 1; Nutrient sensing; Energy homeostasis; Insulin resistance; Glucose homeostasis; Insulin; Obesity; Cell biology; Signal transduction; Medicine; G protein-coupled receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379165,0.00006747236,0.00008423116,0.00003182695,0.00002571937,0.00000478049,0.00004169863,0.000483489,0.00002905184],"category_scores_gemma":[0.00002488561,0.00006076946,0.00002458131,0.00004543967,0.000009713413,0.000003144048,0.00003602848,0.0002388613,0.000001508258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006669574,"about_ca_system_score_gemma":0.00000590559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001223829,"about_ca_topic_score_gemma":0.00002248283,"domain_scores_codex":[0.9995836,0.00002265505,0.00008165975,0.0001228988,0.00006330211,0.0001258618],"domain_scores_gemma":[0.9997881,0.000002852109,0.00002710068,0.0001046672,0.00002406263,0.00005322499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002145539,0.00003405172,0.02979254,0.00001201453,0.000004373853,1.592713e-7,0.0000556815,0.000007149912,0.9691149,0.000210174,0.0005806265,0.0001669005],"study_design_scores_gemma":[0.0002055236,0.0001190695,0.02258072,0.000008210194,0.000003843451,0.00000216102,0.0000401029,0.000002182799,0.9681867,0.00001062609,0.008759132,0.00008178263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988306,0.0005089209,0.0001539459,0.00003659774,0.0001339895,0.00007851464,0.000005265137,0.000003973861,0.00024826],"genre_scores_gemma":[0.9983673,0.0000196792,0.0005419602,0.00022786,0.0002630539,0.000002489023,0.00001970191,0.000008434306,0.0005495224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008178505,"threshold_uncertainty_score":0.372911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006691838515754685,"score_gpt":0.2462264711184705,"score_spread":0.2395346326027158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}