{"id":"W2020280773","doi":"10.1371/journal.ppat.1002447","title":"Granzyme B Inhibits Vaccinia Virus Production through Proteolytic Cleavage of Eukaryotic Initiation Factor 4 Gamma 3","year":2011,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Manitoba; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Vaccinia; Granzyme B; Cytotoxic T cell; Virology; Biology; Protein biosynthesis; Virus; Chemistry; Cell biology; Molecular biology; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855577,0.0002095567,0.0002115504,0.00008062333,0.00008117838,0.00001002981,0.0002107413,0.0001741473,0.0001215093],"category_scores_gemma":[0.0001841699,0.000201287,0.0001079033,0.0002142257,0.00007956434,0.00001665011,0.00008682229,0.0001416861,0.0000671196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002557474,"about_ca_system_score_gemma":0.0001209321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001880882,"about_ca_topic_score_gemma":0.00009030138,"domain_scores_codex":[0.9983708,0.0001837672,0.0003384344,0.0004765399,0.0002914495,0.0003390718],"domain_scores_gemma":[0.998965,0.000008634993,0.0001670946,0.0005688763,0.0002109678,0.00007946349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001324257,0.0003466028,0.003064143,0.00008068314,0.00008254944,0.000005553237,0.0008599649,0.000003060045,0.9933845,0.00001219217,0.0001645099,0.0006719597],"study_design_scores_gemma":[0.000468801,0.002671587,0.01146172,0.00002964188,0.00003212893,0.000008224585,0.00004479584,0.00001184822,0.984849,0.0001555366,0.0000530591,0.0002136574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975913,0.0003000052,0.0001478941,0.00004577479,0.0001257343,0.0008579447,0.00009031491,0.00003270464,0.0008083495],"genre_scores_gemma":[0.9985156,0.0002153716,0.0004993929,0.00007154527,0.0003056145,0.00009499568,0.00009424163,0.00005407931,0.0001491797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008535529,"threshold_uncertainty_score":0.8208244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05989582027090005,"score_gpt":0.278218930326252,"score_spread":0.2183231100553519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}