{"id":"W2020280773","doi":"10.1371/journal.ppat.1002447","title":"Granzyme B Inhibits Vaccinia Virus Production through Proteolytic Cleavage of Eukaryotic Initiation Factor 4 Gamma 3","year":2011,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Manitoba; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Vaccinia; Granzyme B; Cytotoxic T cell; Virology; Biology; Protein biosynthesis; Virus; Chemistry; Cell biology; Molecular biology; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076864,0.0003592971,0.0003275284,0.0002072447,0.0001062235,0.0003595247,0.0002377987,0.0002706455,0.0009521618],"category_scores_gemma":[0.0002809672,0.0001270449,0.0002873391,0.0001345004,0.0002387938,0.0001509308,0.0002183343,0.0006594087,0.0005082159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002529431,"about_ca_system_score_gemma":0.0003038748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003449873,"about_ca_topic_score_gemma":0.00038063,"domain_scores_codex":[0.9998679,0.00003805957,0.00001526766,0.00001407296,0.00002506747,0.00003960783],"domain_scores_gemma":[0.9999187,0.00002402176,0.00001886848,0.00001447849,0.000007791863,0.00001620636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005082435,0.0001941386,0.0001633348,0.00005697409,0.00001371637,0.00004926447,0.0000152976,0.0001269199,0.9943,0.0001323279,0.000112452,0.00432729],"study_design_scores_gemma":[0.0002020634,0.001099317,0.001787241,0.00001093313,0.00001769241,0.0002188594,0.00001791939,0.001121153,0.9922342,0.0001130201,0.003172739,0.000004842202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935625,0.002200258,0.001867913,0.0001575199,0.00006645166,0.00003943729,0.0001114842,0.0001048378,0.001889638],"genre_scores_gemma":[0.9932396,0.001745523,0.001990564,0.00009701108,0.00002189704,0.00004726121,0.0003617288,0.00003056743,0.002465768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009521618,"threshold_uncertainty_score":0.003185272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05989582027090005,"score_gpt":0.278218930326252,"score_spread":0.2183231100553519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}