{"id":"W2020309443","doi":"10.4161/15548627.2014.981914","title":"Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity","year":2014,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Biotechnology and Biological Sciences Research Council; Cancer Research UK","keywords":"ATG12; ATG5; Ubiquitin; Proteasome; Cell biology; Autophagy; Biology; Proteasome inhibitor; Protein degradation; Programmed cell death; Lipid-anchored protein; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781124,0.0001050571,0.000205548,0.0000718613,0.0000488062,0.000009023011,0.00003975147,0.00007535161,0.00007704718],"category_scores_gemma":[0.0001314414,0.00009102399,0.00004426397,0.0001046633,0.00005641905,0.0001493897,0.00001977497,0.00007247005,0.00001126832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000216235,"about_ca_system_score_gemma":0.00004608725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009739072,"about_ca_topic_score_gemma":8.825107e-7,"domain_scores_codex":[0.9992793,0.00006052142,0.0001533056,0.0001865933,0.0001853903,0.0001348669],"domain_scores_gemma":[0.9994833,0.00004930718,0.0001173576,0.0001776591,0.00009394491,0.00007839837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005378078,0.0006579204,0.004650943,0.0007236016,0.0001426235,0.000008830225,0.0003788209,0.000008391219,0.7311821,0.01908903,0.00009389838,0.2425261],"study_design_scores_gemma":[0.00097551,0.0003369441,0.317387,0.00006342396,0.00005344507,0.0000158983,0.00000769075,0.004399749,0.675657,0.0008172169,0.0002135325,0.00007254081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971859,0.000262167,0.0004499412,0.0003038254,0.00004781023,0.0005127039,0.000002473276,0.00006710225,0.00116807],"genre_scores_gemma":[0.9980542,0.00002243529,0.000404571,0.00009109642,0.0000782883,0.00003425032,0.00001487444,0.00001501111,0.001285274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3127361,"threshold_uncertainty_score":0.3711851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272618387705208,"score_gpt":0.2642647700251748,"score_spread":0.2515385861481227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}