{"id":"W2020314417","doi":"10.1371/journal.pone.0005500","title":"Functional Analysis of a Dominant Negative Mutation of Interferon Regulatory Factor 5","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Terry Fox Research Institute","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Transactivation; IRF1; Interferon regulatory factors; Transcription factor; CIITA; Interferon; Cell biology; Molecular biology; Immune system; Genetics; T cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009325838,0.00008789905,0.0003846621,0.0003409684,0.00002870126,0.00000194111,0.00007743999,0.0001004369,0.001355565],"category_scores_gemma":[0.0001300012,0.00007585515,0.0001361542,0.0002388049,0.0001182396,0.00005517851,0.00001652654,0.00009813471,0.00004007163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003025412,"about_ca_system_score_gemma":0.00003093282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002530155,"about_ca_topic_score_gemma":0.000008136965,"domain_scores_codex":[0.9992398,0.0001314687,0.0003412193,0.0001270658,0.00004933956,0.0001110796],"domain_scores_gemma":[0.9993073,0.0001356815,0.0002112137,0.0001695419,0.0001684027,0.000007884165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002014504,0.0008963459,0.0005572293,0.00001351391,0.003085563,4.562699e-7,0.0007217284,0.000006117514,0.9914451,0.0003126834,0.00008091858,0.0008658072],"study_design_scores_gemma":[0.000523196,0.0008388639,0.1501858,0.0000588676,0.0006702722,0.00000138603,0.0001804589,0.00002852809,0.8473989,0.0000424526,0.000010954,0.00006029866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987223,0.0004547242,0.0002149729,0.00007652002,0.00004913262,0.0000981926,0.00004546974,0.00001173802,0.0003270163],"genre_scores_gemma":[0.99791,0.00001699083,0.00007198615,0.00003486895,0.000005423059,0.000003567745,0.00006915019,0.000003886471,0.001884092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1496286,"threshold_uncertainty_score":0.9995573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03259120798565344,"score_gpt":0.2371780269838826,"score_spread":0.2045868189982291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}