{"id":"W2020314417","doi":"10.1371/journal.pone.0005500","title":"Functional Analysis of a Dominant Negative Mutation of Interferon Regulatory Factor 5","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Terry Fox Research Institute","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Transactivation; IRF1; Interferon regulatory factors; Transcription factor; CIITA; Interferon; Cell biology; Molecular biology; Immune system; Genetics; T cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002050677,0.0006663761,0.0001964447,0.0002355024,0.0001949397,0.0002660867,0.0003861722,0.0004872964,0.001537815],"category_scores_gemma":[0.0002067735,0.0001546899,0.0003960708,0.0001177018,0.0002999313,0.00009371435,0.0001636523,0.000645705,0.0006783133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00037347,"about_ca_system_score_gemma":0.0002237447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005818709,"about_ca_topic_score_gemma":0.0005608056,"domain_scores_codex":[0.9997937,0.00004588052,0.00002606093,0.00003916368,0.00006210009,0.00003301959],"domain_scores_gemma":[0.9997483,0.0000781643,0.00008187534,0.00002561695,0.00002148891,0.00004454338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006480258,0.00002096849,0.0001072636,0.00002134246,0.000005788529,0.0002208852,0.00000658233,0.00005593529,0.9988297,0.00007816102,0.00002730343,0.0005613141],"study_design_scores_gemma":[0.00006051875,0.0003979271,0.002463482,0.00001462831,0.00006667558,0.00375707,0.0000300017,0.002814346,0.9867764,0.00007254857,0.003533972,0.00001235918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893814,0.000645961,0.007635091,0.0001846681,0.00008085975,0.00006319601,0.0008384698,0.0001636445,0.001006615],"genre_scores_gemma":[0.9919406,0.0002827592,0.005476459,0.00008068364,0.00001593533,0.00003265724,0.0008763537,0.00005053866,0.001244123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537815,"threshold_uncertainty_score":0.005144477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03259120798565344,"score_gpt":0.2371780269838826,"score_spread":0.2045868189982291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}