{"id":"W2020321288","doi":"10.1021/bi401697j","title":"Structure and Activity of the <i>Streptomyces coelicolor</i> A3(2) β-<i>N</i>-Acetylhexosaminidase Provides Further Insight into GH20 Family Catalysis and Inhibition","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; PROTEO; Institut National de la Recherche Scientifique","funders":"Biotechnology and Biological Sciences Research Council; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Streptomyces coelicolor; Glycosidic bond; Glycoside hydrolase; Enzyme; Stereochemistry; Thermostability; Active site; Hydrolase; Streptomyces; Exoglycosidase; Biochemistry; Glycan; Glycoprotein; Bacteria; Biology; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001073738,0.0003277846,0.0003602367,0.00002058433,0.0001602146,0.00006675067,0.0001990124,0.0003524261,0.0001032091],"category_scores_gemma":[0.0002486253,0.0002556822,0.0001157305,0.0001672417,0.0005281769,0.0001068311,0.0002417661,0.00025672,7.447594e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004842764,"about_ca_system_score_gemma":0.00006580045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008529474,"about_ca_topic_score_gemma":0.00001588383,"domain_scores_codex":[0.9986424,0.00003324572,0.0002903053,0.0005465313,0.0002582919,0.0002292208],"domain_scores_gemma":[0.9986916,0.0001727709,0.000275779,0.0006446676,0.00007902877,0.0001361401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005431704,0.00005898226,0.003371086,0.0008783975,0.00005877761,0.000001482104,0.0004519527,9.335805e-7,0.9889446,0.000003146063,0.0001336584,0.006042679],"study_design_scores_gemma":[0.000414914,0.00001019919,0.0007313567,0.0001373833,0.0001093075,0.00001709434,0.0002519902,0.0001618251,0.9968367,0.0001372663,0.0009019143,0.0002900283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953721,0.000648061,0.000006322558,0.0003416961,0.0000301008,0.00007016385,0.0001118873,0.00004840328,0.003371297],"genre_scores_gemma":[0.9992658,0.00005193694,0.00008571,0.0000811322,0.000166549,0.00002121053,0.00004565216,0.00002734007,0.0002546273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007892133,"threshold_uncertainty_score":0.9999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00546766666690623,"score_gpt":0.1926465355809959,"score_spread":0.1871788689140897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}