{"id":"W2020321288","doi":"10.1021/bi401697j","title":"Structure and Activity of the <i>Streptomyces coelicolor</i> A3(2) β-<i>N</i>-Acetylhexosaminidase Provides Further Insight into GH20 Family Catalysis and Inhibition","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; PROTEO; Institut National de la Recherche Scientifique","funders":"Biotechnology and Biological Sciences Research Council; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Streptomyces coelicolor; Glycosidic bond; Glycoside hydrolase; Enzyme; Stereochemistry; Thermostability; Active site; Hydrolase; Streptomyces; Exoglycosidase; Biochemistry; Glycan; Glycoprotein; Bacteria; Biology; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004526503,0.0003165483,0.0001408637,0.00009479188,0.0001033769,0.0002479047,0.0001907662,0.0001758239,0.0006429789],"category_scores_gemma":[0.00008250133,0.00008313479,0.0002589202,0.0002170302,0.0001422182,0.00008414195,0.00008403073,0.0002847744,0.0002242643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004303396,"about_ca_system_score_gemma":0.000248379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007582486,"about_ca_topic_score_gemma":0.004399781,"domain_scores_codex":[0.9999461,0.000008169384,0.000004374625,0.00001344601,0.00001488371,0.00001295702],"domain_scores_gemma":[0.999943,0.000005126667,0.00001934489,0.000005308071,0.000007872476,0.0000193194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000265946,0.00003942479,0.002416157,0.00003735335,0.0000140304,0.0001854026,0.0000272687,0.001293472,0.9932116,0.0001690473,0.00009151917,0.00224886],"study_design_scores_gemma":[0.00006014321,0.0006597051,0.05940836,0.00001413208,0.00003845998,0.001044089,0.0001639213,0.01465417,0.9181886,0.0001885219,0.005552199,0.00002779481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998009,0.0003073969,0.0004863821,0.00003365777,0.000004395118,0.000003548619,0.0004003775,0.00002379312,0.0007314465],"genre_scores_gemma":[0.9970616,0.0001399284,0.0007581457,0.00001406387,0.000001737497,0.000003511226,0.001257881,0.000009368968,0.000753734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007582486,"threshold_uncertainty_score":0.0150767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00546766666690623,"score_gpt":0.1926465355809959,"score_spread":0.1871788689140897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}