{"id":"W2020343336","doi":"10.1155/2012/947147","title":"Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme","year":2012,"lang":"en","type":"article","venue":"International Journal of Alzheimer s Disease","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université Laval","funders":"Canadian Institutes of Health Research; Alzheimer Society","keywords":"Ribozyme; Gene silencing; Medicine; Protein expression; Computational biology; Amyloid (mycology); Bioinformatics; Cell biology; RNA; Cancer research; Molecular biology; Genetics; Pathology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789375,0.000319102,0.000236961,0.0001335451,0.00008966985,0.0002510886,0.0002213805,0.0002461828,0.0004483987],"category_scores_gemma":[0.0001583065,0.0001190017,0.0002320583,0.00007380295,0.0002555397,0.0001646705,0.0001718869,0.0003767677,0.0001641699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002332608,"about_ca_system_score_gemma":0.000140461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001960996,"about_ca_topic_score_gemma":0.0001958912,"domain_scores_codex":[0.9999033,0.00001362348,0.00001368848,0.00003228954,0.0000216041,0.00001542059],"domain_scores_gemma":[0.9999266,0.00002326268,0.00002171006,0.000008966406,0.000008623731,0.00001093349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002405178,0.00000897511,0.00006284562,0.00001390166,0.00000286408,0.00004223334,0.0000109774,0.0001590608,0.9982109,0.0003005549,0.00001621719,0.001147463],"study_design_scores_gemma":[0.00001258833,0.0001599991,0.0002730698,0.000002618763,0.00001104241,0.0001383434,0.000007090859,0.002390967,0.9954591,0.00008067909,0.00146097,0.000003594826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9364369,0.000830326,0.05979221,0.0001469159,0.00008554819,0.00006468839,0.0001970866,0.0002852072,0.002161249],"genre_scores_gemma":[0.980656,0.0004827091,0.01641779,0.00005624616,0.00001278667,0.00004183433,0.0002293864,0.00004284307,0.002060383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004483987,"threshold_uncertainty_score":0.001692474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552588252294543,"score_gpt":0.2840475892808725,"score_spread":0.2585217067579271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}