{"id":"W2020348358","doi":"10.1016/j.cellsig.2008.08.013","title":"Membrane signalling complexes: Implications for development of functionally selective ligands modulating heptahelical receptor signalling","year":2008,"lang":"en","type":"review","venue":"Cellular Signalling","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Louis-H Lafontaine; Université de Montréal","funders":"","keywords":"Signalling; G protein-coupled receptor; Functional selectivity; Receptor; Cell biology; Effector; Signal transduction; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008544431,0.001053006,0.002140358,0.0003456393,0.000858604,0.00008186403,0.000796341,0.00100329,0.00009946184],"category_scores_gemma":[0.0001802593,0.001049734,0.001460468,0.0005084708,0.0001222354,0.00001865025,0.0002147074,0.0005658671,0.00001854681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759246,"about_ca_system_score_gemma":0.001366014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004877674,"about_ca_topic_score_gemma":0.000004025246,"domain_scores_codex":[0.9946271,0.0001693966,0.002320744,0.001522108,0.000480701,0.0008799097],"domain_scores_gemma":[0.9966331,0.0003851649,0.001400028,0.0004874947,0.0007991599,0.000295114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005851416,0.0001548118,0.000002079884,0.003467737,0.000964483,0.000001368347,0.0001682104,0.003227071,0.8869809,0.0002233748,0.0001320511,0.1046194],"study_design_scores_gemma":[0.0005359368,0.000285906,3.04905e-7,0.003888142,0.0004376776,0.00002843297,0.00005154997,0.0007870951,0.6283976,0.0001075459,0.3642305,0.001249363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001699848,0.5834723,0.4129623,0.000007592413,0.0002429887,0.001382979,0.0001172481,0.00005254074,0.00006218826],"genre_scores_gemma":[0.01142398,0.8986921,0.08073604,0.00004237693,0.001718549,0.000847595,0.005827958,0.0003997269,0.0003117138],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3640984,"threshold_uncertainty_score":0.9991953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0570743249788814,"score_gpt":0.2986460385664156,"score_spread":0.2415717135875342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}