{"id":"W2020363669","doi":"10.1101/gad.1837309","title":"SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state","year":2009,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Broad Institute; W. M. Keck Foundation","keywords":"Biology; Chromatin; Chromatin immunoprecipitation; PRC2; Polycomb-group proteins; H3K4me3; Histone; Histone methylation; Cell biology; Histone methyltransferase; Histone code; Histone H3; Genetics; Gene; Nucleosome; Transcription factor; DNA methylation; Promoter; Gene expression; Repressor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001454196,0.0004414665,0.0002863628,0.0002857067,0.0002463176,0.0005631662,0.0004427301,0.0002717905,0.002589473],"category_scores_gemma":[0.0002383176,0.0002996001,0.0003053486,0.0002043461,0.0002983615,0.0001607189,0.0006234908,0.0005433125,0.000777169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003978492,"about_ca_system_score_gemma":0.0002735396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006601464,"about_ca_topic_score_gemma":0.001077742,"domain_scores_codex":[0.9998171,0.00001981761,0.00001907589,0.00005237924,0.00006130963,0.00003036622],"domain_scores_gemma":[0.9997923,0.00003868595,0.00006252989,0.00002382858,0.00001874733,0.00006397704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005111918,0.00001045264,0.0008938542,0.00003744341,0.000008480182,0.00009140414,0.000009975198,0.00009505849,0.9967996,0.0001270258,0.00007849206,0.001797115],"study_design_scores_gemma":[0.00001482757,0.00006916402,0.0265797,0.00000889207,0.00004100022,0.0007226334,0.0000271656,0.001633473,0.9666988,0.0001416309,0.004055373,0.00000727303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843102,0.004347743,0.005457654,0.000181371,0.00007381399,0.00001538292,0.001024966,0.0002208033,0.004368233],"genre_scores_gemma":[0.9928002,0.001026189,0.001162059,0.00006335798,0.0000113613,0.00001294282,0.001171863,0.00003722787,0.003714767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002589473,"threshold_uncertainty_score":0.008662641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007578706316734282,"score_gpt":0.2324662066385524,"score_spread":0.2248875003218181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}