{"id":"W2020385236","doi":"10.2174/092986707782793826","title":"Glycosylation of HIV-1 gp120 V3 Loop: Towards the Rational Design of a Synthetic Carbohydrate Vaccine","year":2007,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Epitope; Glycosylation; Rational design; HIV vaccine; V3 loop; Glycan; Antigen; Monoclonal antibody; Immunogenicity; Antibody; Chemistry; Virology; Computational biology; Biochemistry; Biology; Glycoprotein; Human immunodeficiency virus (HIV); Immunology; Vaccine trial; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002431974,0.0004291637,0.000386364,0.0001802257,0.0001410985,0.0004162151,0.0003409326,0.000411448,0.0007032804],"category_scores_gemma":[0.000148031,0.0002127201,0.0003649183,0.0002681117,0.0002283969,0.0004262144,0.0002834739,0.000703554,0.000449867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004461389,"about_ca_system_score_gemma":0.0004204349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003508991,"about_ca_topic_score_gemma":0.0005950012,"domain_scores_codex":[0.999923,0.00001634295,0.000004346483,0.00001199568,0.00002381264,0.0000205861],"domain_scores_gemma":[0.9999793,0.000002919895,0.000005889737,0.000001775436,0.000004100168,0.000006120861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003357909,0.0002564213,0.0004283361,0.001107642,0.00006044417,0.0005792139,0.000129843,0.05581524,0.8793848,0.0146669,0.00102794,0.04620741],"study_design_scores_gemma":[0.000516363,0.005626863,0.001569097,0.0003834405,0.0002348558,0.00134354,0.0002325686,0.08264641,0.7575644,0.01374201,0.1360279,0.0001125908],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7577916,0.05858625,0.1595684,0.001619644,0.0003271329,0.0009492782,0.0008661174,0.0003928837,0.01989872],"genre_scores_gemma":[0.812534,0.06039526,0.1194862,0.0005084627,0.00008108509,0.0003884435,0.0008136275,0.00008194863,0.005710964],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0007032804,"threshold_uncertainty_score":0.003237009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08672105820188898,"score_gpt":0.3720435383093804,"score_spread":0.2853224801074914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}