{"id":"W2020411768","doi":"10.1002/(sici)1097-4652(200006)183:3<314::aid-jcp3>3.0.co;2-j","title":"Thrombin-stimulated phosphatidylinositol 3-kinase activity in platelets is associated with activation of PYK2 tyrosine kinase: activation of both enzymes is aggregation independent","year":2000,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"","keywords":"Phosphatidylinositol; Thrombin; Tyrosine kinase; Bruton's tyrosine kinase; Platelet; Platelet activation; Enzyme; Kinase; Chemistry; Proto-oncogene tyrosine-protein kinase Src; Biochemistry; Cell biology; Signal transduction; Internal medicine; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338281,0.0003381484,0.0001974546,0.0002410298,0.0001784131,0.0003785767,0.0001233235,0.0002958507,0.000953703],"category_scores_gemma":[0.0001441222,0.000135787,0.0003203233,0.0003023328,0.000175264,0.0003150843,0.0002867901,0.0006041457,0.000315807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002385392,"about_ca_system_score_gemma":0.0001722516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002509412,"about_ca_topic_score_gemma":0.000291564,"domain_scores_codex":[0.9998528,0.00002033023,0.00001262597,0.00002836568,0.00004781405,0.0000380773],"domain_scores_gemma":[0.999913,0.00001426653,0.00003645725,0.000008981433,0.0000119119,0.00001539074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002019615,0.00002271956,0.000999197,0.00008785561,0.00001521614,0.0002534728,0.00002534216,0.00004379017,0.9964675,0.00009295753,0.00004704586,0.001743048],"study_design_scores_gemma":[0.00004392183,0.0003444869,0.07000165,0.00001324487,0.00004810927,0.003721806,0.00006418202,0.001782784,0.9204064,0.0002257372,0.00333228,0.00001546704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906431,0.004105741,0.003959127,0.000128386,0.0000247123,0.00002684399,0.0002093862,0.00003566461,0.0008672068],"genre_scores_gemma":[0.9944283,0.001920908,0.00202556,0.0000496782,0.00002784566,0.00004400938,0.0003622966,0.000009031443,0.001132366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000953703,"threshold_uncertainty_score":0.003190458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167900290489484,"score_gpt":0.2472182548647366,"score_spread":0.2355392519598417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}