{"id":"W2020473861","doi":"10.1007/s11010-009-0326-8","title":"Central role of guanylyl cyclase in natriuretic peptide signaling in hypertension and metabolic syndrome","year":2009,"lang":"en","type":"review","venue":"Molecular and Cellular Biochemistry","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Natriuretic peptide; Vasodilation; Internal medicine; Endocrinology; Second messenger system; Medicine; NPR1; Metabolic syndrome; NPR2; Kidney; Receptor; Pharmacology; Obesity; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001568149,0.0003575725,0.001378938,0.0002049675,0.00001536675,0.00001275995,0.0000617882,0.000301319,0.00001120949],"category_scores_gemma":[0.00002961294,0.0003072999,0.0002148313,0.000239848,0.00005326452,0.00001547018,0.00006315651,0.0002838426,0.00000128485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005286351,"about_ca_system_score_gemma":0.0000968106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004163274,"about_ca_topic_score_gemma":0.000001210553,"domain_scores_codex":[0.998448,0.00006134802,0.0004820466,0.0004536845,0.0001946603,0.0003602394],"domain_scores_gemma":[0.9994031,0.00001952745,0.0001051577,0.0002809429,0.00001745172,0.0001737999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009999454,0.001317423,0.0007877295,0.05008918,0.0008212182,0.02282125,0.0001178979,0.000004509604,0.346026,0.0002189149,0.0000728889,0.577623],"study_design_scores_gemma":[0.008200292,0.0006194582,0.00025767,0.05951488,0.009923277,0.003834337,0.0004521018,0.0001123924,0.5552239,0.0002838605,0.3593421,0.00223579],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1978755,0.8014575,0.000006372162,0.00004684457,0.000009708472,0.0004471368,0.000004728522,0.000009500311,0.0001427132],"genre_scores_gemma":[0.3648524,0.6344954,0.0003130015,0.00003573529,0.00001638879,0.00001878918,0.0001644167,0.00002815648,0.00007561703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5753872,"threshold_uncertainty_score":0.9999379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008994073072286925,"score_gpt":0.2354982436227039,"score_spread":0.226504170550417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}