{"id":"W2020521224","doi":"10.1002/embj.201386386","title":"E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis","year":2014,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"SLAC National Accelerator Laboratory; Pacific Northwest National Laboratory; Biological and Environmental Research; Howard Hughes Medical Institute; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; U.S. Public Health Service; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"Biology; Effector; Shigella; Pathogenesis; Microbiology; Shigella flexneri; Kinase; Virology; Immunology; Cell biology; Genetics; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001089242,0.0001126772,0.000127298,0.00003041859,0.0003380275,0.00005238091,0.0003483739,0.00006250638,0.00008549078],"category_scores_gemma":[0.0002393313,0.00006056481,0.0001313498,0.00008345345,0.0001416229,0.000004538693,0.0001242716,0.0002096157,0.00001821858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001105969,"about_ca_system_score_gemma":0.00004614636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000169951,"about_ca_topic_score_gemma":0.00001538291,"domain_scores_codex":[0.9987389,0.0004740525,0.000167652,0.000137708,0.0002476035,0.0002340807],"domain_scores_gemma":[0.9991978,0.00006246078,0.0001427796,0.0003951097,0.000120081,0.00008171617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002322412,0.00002756649,0.0009008742,0.00001802718,0.00004576179,0.000003162778,0.00004789516,0.0001593944,0.9931828,0.00003634307,0.0002185635,0.005127333],"study_design_scores_gemma":[0.0005485626,0.0001734974,0.04189715,0.00001976588,0.00001625089,0.0001146022,0.00002444442,0.0002525126,0.9516295,0.0001475162,0.005087685,0.00008853096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977077,0.0003469372,0.0003580108,0.0007742753,0.0001074766,0.0001642626,0.000006128801,0.000004537405,0.0005306893],"genre_scores_gemma":[0.9985565,0.0001507428,0.00004227632,0.00005756792,0.0003997498,0.000007021536,0.000002772341,0.00001555656,0.0007678181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04155336,"threshold_uncertainty_score":0.2599868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008430234554380474,"score_gpt":0.2494589652294133,"score_spread":0.2410287306750328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}