{"id":"W2020545247","doi":"10.1074/jbc.m400933200","title":"Activation of Adenovirus Type 2 Early Region 4 ORF4 Cytoplasmic Death Function by Direct Binding to Src Kinase Domain","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; Cell biology; Biology; Src family kinase; SH3 domain; Programmed cell death; Kinase; Signal transduction; Tyrosine kinase; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000329026,0.000154925,0.0002309783,0.0000489374,0.00005520002,0.00001647461,0.0002381679,0.0002834455,0.00003527923],"category_scores_gemma":[0.0002769048,0.0001198395,0.0001287854,0.0002084008,0.00006273367,0.000008402214,0.00006112255,0.0002253495,0.000006019854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009637456,"about_ca_system_score_gemma":0.0001167162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006716853,"about_ca_topic_score_gemma":0.000001116997,"domain_scores_codex":[0.9988958,0.00006167948,0.0003545783,0.000231955,0.0002248215,0.0002311214],"domain_scores_gemma":[0.9991298,0.00002949488,0.0002709063,0.0001952064,0.0002196915,0.0001548984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005728135,0.0001293588,0.001654579,0.00001361691,0.00006019495,0.0000106712,0.00001933286,0.0001199854,0.9909928,0.000002347923,0.0003823304,0.0008865767],"study_design_scores_gemma":[0.0008583945,0.003829445,0.0009656348,0.00004728423,0.00001041259,0.00003997727,0.00004627002,4.046199e-7,0.9923006,0.000146571,0.001618458,0.000136557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983694,0.000398785,0.0006487785,0.0001572155,0.00006174447,0.0000834919,0.00001222121,0.000006768305,0.0002615903],"genre_scores_gemma":[0.9989965,0.0002105262,0.0002645495,0.0001033575,0.0002736724,0.00000295579,0.00004065987,0.0000145057,0.00009330388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00486974,"threshold_uncertainty_score":0.4886914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02913310982192165,"score_gpt":0.2851173760716484,"score_spread":0.2559842662497268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}