{"id":"W2020547117","doi":"10.1074/jbc.m311310200","title":"Amino Acid Substitution at the Dimeric Interface of Human Manganese Superoxide Dismutase","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Manganese; Superoxide dismutase; Substitution (logic); Chemistry; Amino acid; Superoxide; Amino acid substitution; Biochemistry; Antioxidant; Enzyme; Computer science; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187801,0.0003725377,0.0002685747,0.0001047653,0.0001740484,0.0002176156,0.0002412241,0.0003582565,0.0009906334],"category_scores_gemma":[0.0002635002,0.0001690683,0.0002858944,0.0001342323,0.0002419568,0.0001854509,0.0002424463,0.0005027606,0.0004815531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966359,"about_ca_system_score_gemma":0.0002281218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005600247,"about_ca_topic_score_gemma":0.0006362273,"domain_scores_codex":[0.9998492,0.00004028756,0.00002244923,0.0000310506,0.00003895271,0.00001806277],"domain_scores_gemma":[0.9998106,0.00003285358,0.00005374554,0.00002547189,0.00001862675,0.00005874595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00076378,0.0001178245,0.0009214751,0.0000509902,0.00002024074,0.0004957564,0.00003734399,0.0004897316,0.9933055,0.0002371596,0.00007429679,0.003485935],"study_design_scores_gemma":[0.000176577,0.001178864,0.008345405,0.00001630162,0.00007370414,0.002952399,0.00006517811,0.003651248,0.9799963,0.000183218,0.003335764,0.00002507093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965463,0.0003066076,0.002381481,0.00007084452,0.00005151326,0.00002469618,0.0001101594,0.00003344735,0.0004748356],"genre_scores_gemma":[0.9960843,0.000192892,0.002734657,0.00005499546,0.000009330072,0.0000090666,0.0001863898,0.00001764701,0.0007105118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009906334,"threshold_uncertainty_score":0.003313959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972711587718336,"score_gpt":0.2757492239264657,"score_spread":0.2560221080492824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}