{"id":"W2020591166","doi":"10.1016/j.molcel.2011.08.021","title":"MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes","year":2011,"lang":"en","type":"article","venue":"Molecular Cell","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Cell cycle; Biology; Psychological repression; Downregulation and upregulation; microRNA; Cell biology; Cell cycle checkpoint; Restriction point; Cell; Gene family; Gene; Genetics; Cell cycle progression; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002568603,0.0001471624,0.0001122867,0.00009891499,0.00003723449,0.000008662505,0.0002292397,0.0001379066,0.00002091336],"category_scores_gemma":[0.00005777439,0.0001364544,0.00007597466,0.0002557246,0.00005360829,0.000004245708,0.0001261182,0.00004668123,0.000007062562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006277773,"about_ca_system_score_gemma":0.00007535836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005531612,"about_ca_topic_score_gemma":0.0001396668,"domain_scores_codex":[0.998861,0.0002512897,0.0002211033,0.000318471,0.0001422197,0.0002058733],"domain_scores_gemma":[0.9991701,0.000008715913,0.0001290932,0.0005454883,0.00008813976,0.00005841923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003336085,0.00009943388,0.0006737233,0.00004240474,0.000005012592,0.000001545925,0.000218584,0.000649769,0.9976004,0.000008522674,0.0001083272,0.0002586262],"study_design_scores_gemma":[0.0003874447,0.0001004276,0.0530393,0.00002681382,0.00001623318,0.000001108329,0.00008062521,0.0001757084,0.9445389,0.0001192334,0.001366733,0.0001474514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933789,0.0007898917,0.004334831,0.00008613476,0.00006763942,0.0004759061,0.0000148729,0.000008362036,0.0008434645],"genre_scores_gemma":[0.9981747,0.00001939197,0.001252838,0.0001591848,0.00001002109,0.00002776575,0.00005498798,0.00003349041,0.0002675723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05306152,"threshold_uncertainty_score":0.5564451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007790035109362174,"score_gpt":0.2087780024322441,"score_spread":0.2009879673228819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}