{"id":"W2020597676","doi":"10.1038/cdd.2015.45","title":"Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute of Dental and Craniofacial Research; National Institute on Aging; University at Buffalo; Agricultural Research Service; National Institute of Arthritis and Musculoskeletal and Skin Diseases; U.S. Department of Agriculture","keywords":"NFAT; Osteoclast; Cell biology; Bone remodeling; Ectopic expression; Knockout mouse; Haematopoiesis; Cellular differentiation; Endocrinology; Signal transduction; Internal medicine; Osteoporosis; Homeostasis; Biology; Chemistry; Transcription factor; Medicine; Receptor; Stem cell; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002798055,0.0005813927,0.0003529177,0.0007630166,0.0003964503,0.0007717344,0.0003833751,0.0006092263,0.002699249],"category_scores_gemma":[0.0001960112,0.0003834213,0.0003996691,0.0003833035,0.0006970452,0.0002806575,0.0005363871,0.001275145,0.0008096421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006268842,"about_ca_system_score_gemma":0.0006383738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009739376,"about_ca_topic_score_gemma":0.002415876,"domain_scores_codex":[0.9996935,0.00006571485,0.00001668678,0.00003928671,0.00009225016,0.00009253414],"domain_scores_gemma":[0.9998839,0.000008982747,0.00002713673,0.00001049892,0.00001636786,0.00005311755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002374167,0.0001339973,0.001818975,0.0001409334,0.00003433744,0.0005904655,0.00003871454,0.0002779963,0.9833983,0.002641019,0.001517549,0.007033534],"study_design_scores_gemma":[0.0004628886,0.001010434,0.07596844,0.00008735753,0.0002399227,0.003228874,0.0004466527,0.002972553,0.884281,0.002935525,0.0283247,0.00004165074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595719,0.0204145,0.005413299,0.0025676,0.0004753344,0.00005911355,0.001004347,0.0004086667,0.01008526],"genre_scores_gemma":[0.9841689,0.004587988,0.001511961,0.0003856485,0.00005791895,0.00004589406,0.0004603714,0.00003822988,0.008743124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002699249,"threshold_uncertainty_score":0.009029925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170924718931018,"score_gpt":0.2185068138218179,"score_spread":0.201414341928716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}