{"id":"W2020597676","doi":"10.1038/cdd.2015.45","title":"Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute of Dental and Craniofacial Research; National Institute on Aging; University at Buffalo; Agricultural Research Service; National Institute of Arthritis and Musculoskeletal and Skin Diseases; U.S. Department of Agriculture","keywords":"NFAT; Osteoclast; Cell biology; Bone remodeling; Ectopic expression; Knockout mouse; Haematopoiesis; Cellular differentiation; Endocrinology; Signal transduction; Internal medicine; Osteoporosis; Homeostasis; Biology; Chemistry; Transcription factor; Medicine; Receptor; Stem cell; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001402252,0.0001054956,0.0001583492,0.00004883523,0.00002678919,0.00001560504,0.00002818067,0.0001058146,0.000001858591],"category_scores_gemma":[0.00006616959,0.00009046597,0.00002868294,0.00003696152,0.00003691963,0.000007111187,0.00005812522,0.00003183695,2.72192e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003624052,"about_ca_system_score_gemma":0.00002580122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001525685,"about_ca_topic_score_gemma":0.000006811568,"domain_scores_codex":[0.9993001,0.00005943378,0.000194896,0.0002319521,0.00008906008,0.0001246167],"domain_scores_gemma":[0.9996613,0.000005370038,0.0000799497,0.0001074757,0.00004586819,0.0001000309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001660372,0.0001007763,0.07382785,0.0000739988,0.000003333427,0.000003103537,0.00009900018,0.00003131122,0.9228373,0.00006339295,0.00000393806,0.00278997],"study_design_scores_gemma":[0.001962389,0.0002588092,0.1302216,0.00005095229,0.00005467846,0.00001110774,0.0001769992,0.001083583,0.8644758,0.00138048,0.00007466882,0.0002489109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917819,0.006826642,0.001102878,0.00001499558,0.00002321139,0.0001822147,0.000008865189,0.000006298979,0.00005299585],"genre_scores_gemma":[0.9988927,0.0001264152,0.0007708704,0.00001303429,0.00004388201,0.00001231445,0.00007361497,0.000008428206,0.00005871191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05836148,"threshold_uncertainty_score":0.3689095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170924718931018,"score_gpt":0.2185068138218179,"score_spread":0.201414341928716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}