{"id":"W2020614807","doi":"10.1002/jnr.21636","title":"Sustained striatal ciliary neurotrophic factor expression negatively affects behavior and gene expression in normal and R6/1 mice","year":2008,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Ciliary neurotrophic factor; Huntingtin; Biology; Huntington's disease; Transgene; Genetically modified mouse; Neurotrophic factors; Striatum; Internal medicine; Endocrinology; Neuroscience; Cell biology; Mutant; Gene; Genetics; Medicine; Dopamine; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003583977,0.001164934,0.0007111467,0.001886394,0.0004517341,0.0007374735,0.0008305538,0.001539143,0.002295178],"category_scores_gemma":[0.0002367318,0.0006855871,0.0007923741,0.0003819218,0.001143281,0.0005013639,0.0003665663,0.001822883,0.0009830971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009534204,"about_ca_system_score_gemma":0.0003937657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002345219,"about_ca_topic_score_gemma":0.003601746,"domain_scores_codex":[0.9989441,0.0001023022,0.0001251249,0.0003934699,0.0002348106,0.0002001527],"domain_scores_gemma":[0.9991313,0.00006619717,0.0002907056,0.00006259645,0.00004478911,0.0004043962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003261969,0.0001275089,0.0001935971,0.00002330803,0.000009381189,0.0001023455,0.00003085904,0.00004605098,0.9985363,0.0001022288,0.00004896065,0.0004532066],"study_design_scores_gemma":[0.0004063971,0.002596023,0.02318791,0.0000559129,0.0001248847,0.001720185,0.0001911914,0.002544919,0.9652504,0.0002405299,0.003618643,0.00006293906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928352,0.001285044,0.001475838,0.0002242365,0.00005318491,0.0000533719,0.002418325,0.0002702764,0.001384568],"genre_scores_gemma":[0.9767602,0.001898937,0.005418985,0.0002822755,0.00005225807,0.0002287745,0.003557879,0.0003336668,0.01146707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002345219,"threshold_uncertainty_score":0.007678092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1160157614453412,"score_gpt":0.3669300161253786,"score_spread":0.2509142546800374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}