{"id":"W2020673367","doi":"10.1016/j.molcel.2009.06.023","title":"Two-Color Cell Array Screen Reveals Interdependent Roles for Histone Chaperones and a Chromatin Boundary Regulator in Histone Gene Repression","year":2009,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Genomics Institute; Genome Canada","keywords":"Biology; Chromatin; Histone code; Histone H1; Histone H2A; Genetics; Chromatin remodeling; Histone methyltransferase; Histone methylation; Cell biology; Histone; ChIA-PET; Bivalent chromatin; SAP30; Nucleosome; Gene expression; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003130781,0.0005885456,0.0006798455,0.0007826407,0.0004085242,0.0007258288,0.0005713894,0.0005403483,0.003380276],"category_scores_gemma":[0.0002974992,0.0004157149,0.0005059948,0.0004664242,0.0003451206,0.0003028071,0.000741802,0.000918758,0.001199214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004856208,"about_ca_system_score_gemma":0.0003152748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001376624,"about_ca_topic_score_gemma":0.003367166,"domain_scores_codex":[0.999517,0.00006561846,0.00002508034,0.0001294817,0.0001571413,0.0001057313],"domain_scores_gemma":[0.9995128,0.0001421917,0.00007843529,0.00008322824,0.00004545581,0.0001379654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003799354,0.00001734349,0.000221162,0.000004626896,0.000004590632,0.00002580085,0.000004151504,0.00002024402,0.9991273,0.00006541241,0.00006341602,0.0004079423],"study_design_scores_gemma":[0.00001413445,0.00007342047,0.008585421,7.077078e-7,0.00002702106,0.0001925106,0.00002045241,0.001108243,0.9887903,0.00006369756,0.001116539,0.000007635019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678031,0.0009118234,0.02374589,0.0003518793,0.00008763322,0.00005808155,0.002533602,0.0007410492,0.003766812],"genre_scores_gemma":[0.9739113,0.0004120562,0.01128806,0.0004056269,0.00002393318,0.00007241677,0.003400821,0.0002869656,0.01019883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003380276,"threshold_uncertainty_score":0.01130813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004222218213341196,"score_gpt":0.2396497848067389,"score_spread":0.2354275665933977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}