{"id":"W2020673367","doi":"10.1016/j.molcel.2009.06.023","title":"Two-Color Cell Array Screen Reveals Interdependent Roles for Histone Chaperones and a Chromatin Boundary Regulator in Histone Gene Repression","year":2009,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Genomics Institute; Genome Canada","keywords":"Biology; Chromatin; Histone code; Histone H1; Histone H2A; Genetics; Chromatin remodeling; Histone methyltransferase; Histone methylation; Cell biology; Histone; ChIA-PET; Bivalent chromatin; SAP30; Nucleosome; Gene expression; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003343748,0.0002925718,0.0003087171,0.00008834179,0.0001084491,0.000048528,0.0002623207,0.0001845961,0.000008289552],"category_scores_gemma":[0.00002373627,0.0003057192,0.000130575,0.0000626406,0.00007714218,0.000006756726,0.0001259184,0.0001123466,0.00000389339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008093431,"about_ca_system_score_gemma":0.00005796627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002631051,"about_ca_topic_score_gemma":0.00004342076,"domain_scores_codex":[0.9982897,0.00009118648,0.0004314376,0.0006635226,0.0001501875,0.0003739388],"domain_scores_gemma":[0.9990399,0.000009002306,0.000207377,0.0005576942,0.00005684838,0.0001292168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001185305,0.0001732294,0.00008842655,0.00005502643,0.00001180801,0.00002133799,0.0001468303,0.000236666,0.9973171,0.00003774538,0.0002807713,0.00151258],"study_design_scores_gemma":[0.002194104,0.0005824839,0.001556829,0.00005068063,0.00003528091,0.00002382218,0.00008172433,0.0009644371,0.9905695,0.0006962572,0.002814155,0.0004307355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827691,0.006232009,0.007746726,0.0001997184,0.00008016049,0.0005810554,0.00003980474,0.00001849923,0.002332917],"genre_scores_gemma":[0.9799911,0.0001594678,0.01796415,0.0004622021,0.0000846277,0.00004104972,0.0002847052,0.00005106496,0.0009616049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01021742,"threshold_uncertainty_score":0.9999395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004222218213341196,"score_gpt":0.2396497848067389,"score_spread":0.2354275665933977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}