{"id":"W2020692948","doi":"10.1016/j.clinph.2014.04.023","title":"Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS","year":2014,"lang":"de","type":"article","venue":"Clinical Neurophysiology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Sustainable Development Technology Canada","keywords":"Amyotrophic lateral sclerosis; Fasciculation; Motor neuron; Neuroscience; Motor unit; Upper motor neuron; Silent period; Lower motor neuron; Electromyography; Motor cortex; Psychology; Medicine; Transcranial magnetic stimulation; Spinal cord; Internal medicine; Disease; Stimulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001628819,0.0005347118,0.001737266,0.0001592152,0.0001441089,0.00004109335,0.0005492195,0.0009321986,0.001361909],"category_scores_gemma":[0.01999095,0.0004379171,0.0005563356,0.0004445018,0.001906598,0.0001349769,0.000608534,0.003377053,0.005006724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001302968,"about_ca_system_score_gemma":0.0001970837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009671871,"about_ca_topic_score_gemma":0.00001021232,"domain_scores_codex":[0.9874331,0.006509421,0.002254213,0.001900237,0.0005489624,0.00135405],"domain_scores_gemma":[0.9905016,0.006594758,0.000278852,0.001536702,0.0002582795,0.0008297546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03065602,0.01376938,0.3891314,0.0008805267,0.0004785245,0.0006171981,0.0001062526,0.0003933097,0.4643609,0.0007407393,0.003540997,0.09532472],"study_design_scores_gemma":[0.00362502,0.01393224,0.9577011,0.0001184819,0.0001513585,0.000004504121,0.000004414504,0.01306348,0.00003487938,0.0005275359,0.01050825,0.0003287602],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871813,0.0002664831,0.00005115146,0.003528824,0.007404177,0.001085881,0.00001539995,0.0001033066,0.0003634419],"genre_scores_gemma":[0.9885201,0.001962644,0.00008857811,0.004240112,0.004524091,0.00005591185,0.00002759831,0.00009864842,0.0004823031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5685697,"threshold_uncertainty_score":0.9998072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06518262089017898,"score_gpt":0.3672788826606972,"score_spread":0.3020962617705183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}