{"id":"W2020695556","doi":"10.1124/mol.104.009068","title":"Identification of a Potent and Selective Synthetic Agonist at the CRTH2 Receptor","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Agonist; Identification (biology); Receptor; Computational biology; Chemistry; Pharmacology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002536264,0.000121156,0.0001221745,0.00003063305,0.0001218885,0.00001147329,0.0001410281,0.00009985348,0.0001767273],"category_scores_gemma":[0.00002538944,0.00009873888,0.00007447978,0.0000665441,0.0001401092,0.000002758732,0.0001218252,0.00007888337,0.00001762036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002668894,"about_ca_system_score_gemma":0.00003311571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005121982,"about_ca_topic_score_gemma":0.000005244669,"domain_scores_codex":[0.9990318,0.000156115,0.0002305224,0.0002983125,0.00009868938,0.0001845748],"domain_scores_gemma":[0.9995429,0.00001483104,0.0001323943,0.0001718424,0.00008591941,0.00005211465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008146687,0.00004751106,0.00002382916,0.000008822893,0.00008144297,0.000001266071,0.00006874109,0.0003410514,0.9921567,0.0001148873,0.0017044,0.005369923],"study_design_scores_gemma":[0.0003744908,0.0001319534,0.00005202673,0.000003081719,0.00005237537,0.00002462416,0.00002853313,0.0003440449,0.9703827,0.00003883573,0.02846389,0.0001034487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896169,0.001932681,0.006387542,0.001197883,0.0001729075,0.0003956616,0.00001552052,0.000008208235,0.0002727236],"genre_scores_gemma":[0.9981385,0.0002182913,0.0002529889,0.0005819829,0.0001199586,0.00008271095,0.00002647409,0.00001910393,0.0005599485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02675949,"threshold_uncertainty_score":0.4026455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005190862373438755,"score_gpt":0.2524764625936925,"score_spread":0.2472856002202538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}