{"id":"W2020719534","doi":"10.1002/eji.201545462","title":"HSP90 inhibitors decrease AID levels and activity in mice and in human cells","year":2015,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Cancer Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust","keywords":"Somatic hypermutation; Biology; Immunoglobulin class switching; Cancer research; In vivo; Antibody; Isotype; Hsp90; Immunology; B cell; Gene; Monoclonal antibody; Heat shock protein; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561293,0.0001979313,0.0004336428,0.0004093112,0.00006753363,0.00002095048,0.0002320723,0.0001274266,0.00005675486],"category_scores_gemma":[0.0001454888,0.000178046,0.00004828978,0.000130369,0.0002886008,0.0002272655,0.0002089468,0.0007955265,0.00003536493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006115357,"about_ca_system_score_gemma":0.0000764818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008155665,"about_ca_topic_score_gemma":0.00004418697,"domain_scores_codex":[0.9977086,0.001128705,0.0005755589,0.0002125245,0.00003632223,0.0003382504],"domain_scores_gemma":[0.9992759,0.00009119663,0.0003433443,0.0001574347,0.000067512,0.00006463294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004931006,0.0001638815,0.001424138,0.00000588076,0.00006925195,0.0002904936,0.00110821,0.000004483163,0.9904087,0.0001257781,0.0001280523,0.005778012],"study_design_scores_gemma":[0.0146194,0.002534292,0.1716808,0.0002398055,0.00004753285,0.00196753,0.001854772,0.000002795982,0.7949299,0.0006048009,0.01106185,0.000456614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918177,0.00651043,0.00007249542,0.0001930166,0.0006791217,0.0001018573,0.000005561881,0.000009573611,0.000610245],"genre_scores_gemma":[0.9990935,0.0002148954,0.0002417794,0.00009556501,0.00003307645,8.242499e-7,0.000001615896,0.00002477215,0.0002939822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1954789,"threshold_uncertainty_score":0.7260507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178605167111919,"score_gpt":0.2355562563644319,"score_spread":0.2137702046933127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}