{"id":"W2020744895","doi":"10.1182/blood-2011-04-351809","title":"The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; BC Cancer Agency","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Microphthalmia-associated transcription factor; Cell biology; PI3K/AKT/mTOR pathway; Phosphoinositide 3-kinase; Biology; Transcription factor; Mast cell; Stem cell factor; Signal transduction; Haematopoiesis; Stem cell; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008996182,0.0002155865,0.0001207844,0.0001057373,0.000100549,0.000206866,0.0001044407,0.0001721441,0.0005924072],"category_scores_gemma":[0.00006937971,0.00009518835,0.0001106046,0.00007879902,0.0001916601,0.0002059078,0.0001813567,0.0004879287,0.0002951681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003460874,"about_ca_system_score_gemma":0.0001899218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003726459,"about_ca_topic_score_gemma":0.0006421213,"domain_scores_codex":[0.9999171,0.00001137291,0.000006655203,0.00001589961,0.00002468401,0.00002427459],"domain_scores_gemma":[0.9999427,0.000008973959,0.0000242847,0.00000654622,0.000003933259,0.00001350774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000415854,0.000006794116,0.0002066614,0.00001478431,0.000001676953,0.00006495941,0.000006554057,0.00003484343,0.9986034,0.0001711035,0.00002865817,0.0008190236],"study_design_scores_gemma":[0.00001489267,0.0001331786,0.008070167,0.000004138471,0.00001034985,0.0004348126,0.00001533142,0.001127234,0.9874411,0.0001219251,0.00262435,0.000002502256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929178,0.002245869,0.003137951,0.0001396126,0.0000191549,0.00001352312,0.0002231182,0.00006083753,0.00124198],"genre_scores_gemma":[0.9962579,0.001144608,0.001234771,0.00002358056,0.00001109163,0.00001226968,0.0001937611,0.000006187164,0.001115854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005924072,"threshold_uncertainty_score":0.002511084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128021201932625,"score_gpt":0.1801560580689686,"score_spread":0.1673539378757061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}