{"id":"W2020804982","doi":"10.1021/jm501963e","title":"Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Canada; Engineering and Physical Sciences Research Council; Eli Lilly Canada; Boehringer Ingelheim Stiftung; Cancer Research UK; Novartis Foundation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Genome Canada; Wellcome; GlaxoSmithKline; Bayer; Pfizer","keywords":"Bromodomain; Chemistry; Chromatin; Computational biology; In vitro; In vivo; Intramolecular force; BRD4; Biochemistry; Stereochemistry; Histone; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007323638,0.000125941,0.0002579227,0.00001993526,0.00002381293,0.000006582293,0.0002364306,0.0001579086,0.00002746631],"category_scores_gemma":[0.0009454908,0.00008055946,0.00007232501,0.00007625636,0.0002162437,0.00000718704,0.00007014203,0.0002385089,8.938125e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001899948,"about_ca_system_score_gemma":0.0002783075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003309269,"about_ca_topic_score_gemma":1.460272e-7,"domain_scores_codex":[0.998863,0.00006196798,0.0004904201,0.0001214981,0.0003269493,0.0001360978],"domain_scores_gemma":[0.9987521,0.00003562793,0.0005531976,0.0001574754,0.0003502135,0.0001513723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002770608,0.00003408169,0.0003195839,0.00009290058,0.00005600618,0.000004547597,0.0001506901,0.0000258093,0.9946976,0.00000452324,0.003979964,0.0003572149],"study_design_scores_gemma":[0.001177818,0.0002406725,0.00004677194,0.0001041866,0.00004657065,0.0003032013,0.0005933614,0.0000608935,0.9952784,0.0002016676,0.001867208,0.00007929676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992516,0.003172625,0.003477352,0.0003982724,0.00008285345,0.0001052252,0.000006632072,0.00000195824,0.0002390802],"genre_scores_gemma":[0.9953605,0.00009949972,0.00388685,0.00006623827,0.0004861533,0.000001309682,0.000009403609,0.00001098349,0.00007909694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003073125,"threshold_uncertainty_score":0.328512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295912093597482,"score_gpt":0.2352159376367886,"score_spread":0.2222568167008138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}