{"id":"W2020804982","doi":"10.1021/jm501963e","title":"Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Canada; Engineering and Physical Sciences Research Council; Eli Lilly Canada; Boehringer Ingelheim Stiftung; Cancer Research UK; Novartis Foundation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Genome Canada; Wellcome; GlaxoSmithKline; Bayer; Pfizer","keywords":"Bromodomain; Chemistry; Chromatin; Computational biology; In vitro; In vivo; Intramolecular force; BRD4; Biochemistry; Stereochemistry; Histone; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002479091,0.0004629768,0.0004370542,0.0002373785,0.000253174,0.0003935593,0.0005617812,0.000435516,0.001361964],"category_scores_gemma":[0.0001822595,0.000239851,0.0002829158,0.0002335098,0.0002430991,0.0002902854,0.0003199235,0.0009213274,0.000728823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005699397,"about_ca_system_score_gemma":0.0007943579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006103779,"about_ca_topic_score_gemma":0.001546121,"domain_scores_codex":[0.9998878,0.00001677296,0.000005774058,0.00002181103,0.00003435423,0.0000335014],"domain_scores_gemma":[0.9999419,0.000005138879,0.00001373217,0.000006295445,0.00001373948,0.0000191791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002638201,0.0002018241,0.0001895821,0.0002263277,0.00003331341,0.0002474983,0.00006517511,0.006685618,0.976235,0.002777511,0.0005386001,0.01253572],"study_design_scores_gemma":[0.000164912,0.001098415,0.0003632601,0.00001196575,0.00003952908,0.0003600014,0.0000229872,0.00557926,0.9734181,0.0002601836,0.01865573,0.00002560688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8558897,0.006335344,0.1145674,0.0008928445,0.0001367168,0.001373057,0.001844118,0.0007033835,0.01825746],"genre_scores_gemma":[0.936124,0.004222528,0.0517755,0.0002076558,0.00002334836,0.0003011626,0.001528049,0.00005914462,0.005758652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361964,"threshold_uncertainty_score":0.004556239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295912093597482,"score_gpt":0.2352159376367886,"score_spread":0.2222568167008138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}