{"id":"W2020805901","doi":"10.1016/j.bmcl.2008.12.048","title":"SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103)","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Benzamide; Chemistry; HDAC1; Histone deacetylase; Histone deacetylase inhibitor; In vivo; Small molecule; Acetylation; Pharmacokinetics; In vitro; Lead compound; Recombinant DNA; Cancer research; Histone; Biochemistry; Stereochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002277782,0.0003108427,0.0003304771,0.0001651912,0.0001665988,0.000271617,0.000480078,0.000252461,0.001985475],"category_scores_gemma":[0.0002214417,0.0001428625,0.0002691028,0.0002003824,0.0002152259,0.0001695431,0.0001073956,0.0006172671,0.0004809338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003639424,"about_ca_system_score_gemma":0.0004349971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002221747,"about_ca_topic_score_gemma":0.003182671,"domain_scores_codex":[0.9999305,0.00001453062,0.000005661383,0.00001195384,0.00001461463,0.00002276243],"domain_scores_gemma":[0.9999074,0.0000150569,0.0000173309,0.00001109636,0.00001437843,0.00003476345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002800746,0.001069275,0.0005687957,0.0002273487,0.00005063267,0.0002437633,0.00005955054,0.002939133,0.975546,0.0004203266,0.0006409649,0.01543348],"study_design_scores_gemma":[0.002577739,0.02886911,0.006530406,0.00003705025,0.0002756263,0.001182128,0.00006702641,0.003643857,0.9399474,0.000141807,0.01669311,0.00003471777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863889,0.005795954,0.001837498,0.0001734239,0.00008117697,0.0002270535,0.001038668,0.00009005838,0.004367271],"genre_scores_gemma":[0.9897066,0.0037719,0.001929521,0.00009312304,0.00002157182,0.00008841787,0.002049635,0.00001423109,0.002324926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002221747,"threshold_uncertainty_score":0.006642044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04702229651429136,"score_gpt":0.2891897136069961,"score_spread":0.2421674170927047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}