{"id":"W2020815084","doi":"10.1073/pnas.0600538103","title":"Repair of DNA–polypeptide crosslinks by human excision nuclease","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; York University; University of Rochester; National Institutes of Health; Harvard University; Memorial Sloan-Kettering Cancer Center","keywords":"Nucleotide excision repair; Nuclease; DNA; DNA repair; Replication protein A; Base excision repair; DNA ligase; DNA repair protein XRCC4; Biochemistry; Molecular biology; DDB1; Biology; Chemistry; Gene; DNA-binding protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000752676,0.00008019635,0.0001087964,0.00005717443,0.0001236622,0.0000080686,0.000504526,0.0001190325,0.000009392876],"category_scores_gemma":[0.0001966825,0.00005899049,0.0001191354,0.0002255116,0.0006165412,0.00001857496,0.0001698275,0.00006757546,5.554429e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009706377,"about_ca_system_score_gemma":0.00002065355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001442185,"about_ca_topic_score_gemma":1.307939e-7,"domain_scores_codex":[0.9986673,0.000005053864,0.0003151592,0.000240852,0.0006539128,0.0001176978],"domain_scores_gemma":[0.9993515,0.00001329516,0.0003837405,0.00001445689,0.0002142628,0.00002274379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000123259,0.0000542825,0.00234769,0.00002412523,0.000006534097,2.314396e-9,0.000009704223,0.00001546564,0.9780266,0.01267127,0.006790158,0.0000417989],"study_design_scores_gemma":[0.0001434082,0.0001028226,0.01110701,0.00003088184,0.000006463111,0.000002452983,0.00003513425,0.00009082945,0.9740426,0.01299797,0.00137689,0.0000635245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938557,0.0001461445,0.000002206395,0.0002199395,0.00001081475,0.0001002804,0.00002270392,0.000008791082,0.005633402],"genre_scores_gemma":[0.9973796,0.000008738944,0.001684662,0.0001094691,0.00007073698,0.000003666408,0.000001059884,0.000005186994,0.0007368958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008759322,"threshold_uncertainty_score":0.2405563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708944105366547,"score_gpt":0.2879663908052683,"score_spread":0.2708769497516028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}