{"id":"W2020831499","doi":"10.1172/jci15420","title":"Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":418,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada)","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; American Heart Association","keywords":"Lactosylceramide; Caveolae; Golgi apparatus; Sphingolipid; Cell biology; Rab; Lipid raft; Ceramide; Vesicular transport protein; Sphingomyelin; Biology; Clathrin; Glycosphingolipid; Lipid microdomain; Endocytosis; Chemistry; Biochemistry; Vesicle; Signal transduction; Receptor; Glycolipid; Cholesterol; GTPase; Membrane; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000207622,0.0003596605,0.0001696159,0.0002381365,0.0002498709,0.0003471395,0.0001880838,0.0003262631,0.0005504096],"category_scores_gemma":[0.0002144661,0.0001160306,0.0001530187,0.0001082657,0.0002188749,0.0001902396,0.000204329,0.0002995801,0.0003826766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006368421,"about_ca_system_score_gemma":0.0004151064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002109951,"about_ca_topic_score_gemma":0.002245829,"domain_scores_codex":[0.9998888,0.00002173984,0.0000116437,0.0000106889,0.00003788011,0.00002920796],"domain_scores_gemma":[0.9999406,0.000007650066,0.0000104936,0.00001020839,0.0000148954,0.00001609145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008786101,0.00001579246,0.0002196763,0.00003513979,0.000004213967,0.0002547775,0.00001306755,0.0001369396,0.9965363,0.0004824426,0.00007024397,0.002143632],"study_design_scores_gemma":[0.00003661524,0.00009114258,0.002513326,0.000006529698,0.000015617,0.001027545,0.00003200871,0.001581354,0.9907108,0.0001830205,0.003796319,0.000005825534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923847,0.002182948,0.002873772,0.00016139,0.00002168707,0.00003976261,0.0001559305,0.0001215418,0.0020583],"genre_scores_gemma":[0.9921266,0.001741078,0.003345533,0.0000397187,0.0000068932,0.00002752399,0.0002335092,0.00002049341,0.002458696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002109951,"threshold_uncertainty_score":0.004620671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03484175087733286,"score_gpt":0.2877694204625575,"score_spread":0.2529276695852246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}