{"id":"W2020844906","doi":"10.1021/bi602498k","title":"Structure and Mechanism of Spermidine Synthases","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Wellcome Trust","keywords":"Spermidine; Putrescine; Thermotoga maritima; Biochemistry; Polyamine; Chemistry; ATP synthase; Stereochemistry; Enzyme; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002392182,0.0003747231,0.0002917584,0.0002042481,0.0002652799,0.00053104,0.0004790403,0.0006632781,0.0009155833],"category_scores_gemma":[0.0001712489,0.0002400011,0.0001819551,0.0001385276,0.0004042642,0.0004479619,0.0002319519,0.0004831897,0.0008527198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007665728,"about_ca_system_score_gemma":0.0003299013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004470905,"about_ca_topic_score_gemma":0.0002965686,"domain_scores_codex":[0.9998829,0.00001483476,0.000007457954,0.00004681764,0.00003125391,0.0000166183],"domain_scores_gemma":[0.9998729,0.00001213906,0.00002475208,0.00001394705,0.00004542967,0.00003082444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001885328,0.00004060189,0.0009829978,0.0003593235,0.0000191549,0.0004102916,0.00009122288,0.00188585,0.9555448,0.02516932,0.0004126695,0.01489534],"study_design_scores_gemma":[0.00005843033,0.0005236416,0.004445882,0.00005442962,0.00003749079,0.001319145,0.00008878501,0.009262884,0.9379249,0.008187781,0.03806185,0.00003469792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8300827,0.07058951,0.07238764,0.001878251,0.0004701069,0.0001727661,0.0005103304,0.00101283,0.02289588],"genre_scores_gemma":[0.9708053,0.01003146,0.007213964,0.0001384131,0.00009436846,0.00004888904,0.0005302153,0.0000273575,0.0111102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009155833,"threshold_uncertainty_score":0.005561948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004746863483139918,"score_gpt":0.2371228034252011,"score_spread":0.2323759399420612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}