{"id":"W2020846928","doi":"10.1002/hep.26058","title":"Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate","year":2012,"lang":"en","type":"article","venue":"Hepatology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Hospital for Sick Children; National Center for Research Resources; Seattle Children's Research Institute; Children's National Hospital; University of California, Los Angeles; University of Minnesota; Medical College of Wisconsin; Case Western Reserve University; University of Toronto; University of Utah; Children's Hospital of Pittsburgh; National Center for Advancing Translational Sciences; Children's Hospital Colorado; Tufts Medical Center; Nationwide Children's Hospital","keywords":"Urea cycle; Neurocognitive; Phenylbutyrate; Urea; Ammonia; Internal medicine; Glycerol; Chemistry; Medicine; Gastroenterology; Biochemistry; Psychiatry; Cognition; Arginine; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006274828,0.0003692343,0.0008821506,0.0001928686,0.0003813926,0.000442256,0.000224581,0.0005160435,0.0009104906],"category_scores_gemma":[0.001103788,0.0001487797,0.0005063936,0.000233631,0.0003608337,0.0003544588,0.000233729,0.0005649805,0.0001187481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003935623,"about_ca_system_score_gemma":0.000349947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00123761,"about_ca_topic_score_gemma":0.001261404,"domain_scores_codex":[0.9996754,0.0001191945,0.00004135085,0.00007070731,0.00003320704,0.00006008439],"domain_scores_gemma":[0.999088,0.0002239393,0.0003084579,0.0000460447,0.00007527197,0.000258251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1923147,0.003847294,0.7571064,0.0001974392,0.00107335,0.0006350158,0.0002231715,0.0004500641,0.01681666,0.00002744349,0.0003741953,0.02693441],"study_design_scores_gemma":[0.004907854,0.07850324,0.9112431,0.00003840662,0.0006276941,0.000989612,0.0002138116,0.000665993,0.002386516,0.00004813614,0.0003519951,0.00002365283],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994397,0.0003524397,0.00002564299,0.00001830597,0.000005980542,0.00001471096,0.00005387115,0.000001945485,0.0000874195],"genre_scores_gemma":[0.9996328,0.00007222027,0.00004368821,0.0000438029,0.00001014406,0.00001631298,0.000133881,7.837851e-7,0.000046368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123761,"threshold_uncertainty_score":0.003318489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004362432678481151,"score_gpt":0.2130881388999925,"score_spread":0.2087257062215114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}