{"id":"W2020850151","doi":"10.1073/pnas.1112036108","title":"Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"MacEwan University; University of Alberta","funders":"National Cancer Institute; Howard Hughes Medical Institute","keywords":"DNA; Phosphatase; Biochemistry; Biology; DNA repair; Active site; DNA polymerase; Enzyme; Cell biology; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003759415,0.00009864981,0.0001109177,0.0000232095,0.0001425126,0.00001129102,0.0004656111,0.00007986394,0.000009156132],"category_scores_gemma":[0.0001660105,0.0000581029,0.00007415601,0.000127458,0.000885227,0.00002474201,0.0000813508,0.00006497843,6.73416e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000593917,"about_ca_system_score_gemma":0.00002122207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001191822,"about_ca_topic_score_gemma":2.217016e-7,"domain_scores_codex":[0.999175,0.000002448585,0.00017635,0.0002116684,0.0003127076,0.0001218663],"domain_scores_gemma":[0.9994769,0.00005538994,0.0002923149,0.00001773126,0.0001259359,0.00003173585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004083984,0.00004413958,0.001636282,0.00005632094,0.00002945951,4.283307e-9,0.00005341252,0.000004079928,0.9927784,0.004064212,0.0002193734,0.0007059386],"study_design_scores_gemma":[0.0003765007,0.0001338443,0.0177622,0.00002799736,0.0000241925,0.000002898519,0.0001075291,0.00006671132,0.9797193,0.001652193,0.00005916015,0.00006748419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998166,0.0004422948,6.08269e-7,0.0003765421,0.0000150126,0.0001537283,0.0001562984,0.000002472752,0.0006870316],"genre_scores_gemma":[0.9994515,0.00003747816,0.0003462279,0.00008177644,0.00003909203,0.000007201512,0.000001200931,0.000004181831,0.00003137377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01612592,"threshold_uncertainty_score":0.3261656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05051052305210445,"score_gpt":0.2798990135011091,"score_spread":0.2293884904490047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}