{"id":"W2020850151","doi":"10.1073/pnas.1112036108","title":"Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"MacEwan University; University of Alberta","funders":"National Cancer Institute; Howard Hughes Medical Institute","keywords":"DNA; Phosphatase; Biochemistry; Biology; DNA repair; Active site; DNA polymerase; Enzyme; Cell biology; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736125,0.0003371123,0.0002132429,0.00009129172,0.0003040133,0.0004312252,0.0005376294,0.0003927198,0.001049256],"category_scores_gemma":[0.0004063954,0.0002207791,0.0001848626,0.00008504882,0.0004555864,0.0003493374,0.0003080663,0.0006812029,0.0005747383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004325152,"about_ca_system_score_gemma":0.0003598858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004111263,"about_ca_topic_score_gemma":0.0003963231,"domain_scores_codex":[0.9998955,0.00001436431,0.000007674184,0.00002109965,0.00003773502,0.00002361125],"domain_scores_gemma":[0.9998673,0.00002282161,0.00002875136,0.00001541836,0.00002371697,0.00004199587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002770357,0.0001163945,0.001047189,0.0001202089,0.00001122704,0.0005473964,0.00007457544,0.004897703,0.9758807,0.01210241,0.0002183211,0.004706915],"study_design_scores_gemma":[0.0001476281,0.0004955126,0.004803525,0.00002657824,0.0000210086,0.001112976,0.00008675472,0.03335783,0.9453824,0.007292673,0.007246814,0.00002632816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762898,0.001408556,0.01383954,0.0005216998,0.0001078916,0.00005095806,0.0000842975,0.0001742962,0.007523031],"genre_scores_gemma":[0.9963709,0.0003652265,0.00219149,0.00005674849,0.0000114198,0.00002154051,0.0001329294,0.00001462683,0.0008351569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049256,"threshold_uncertainty_score":0.003510118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05051052305210445,"score_gpt":0.2798990135011091,"score_spread":0.2293884904490047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}